Microbiome Restore Protocol

Dr Andrew Orr’s Microbiome Restore Protocol

The Purpose Of The Microbiome Restore

Many inflammatory health conditions can be linked to compromised microbiome and poor gut health. There is now good research and evidence to show the importance of microbiome restore.

Within these poor health states, there is often an overgrowth of “bad” bacteria within your gut. This is a crucial part of treatment for these ailments to restore the microbiome and replenish the “good” bacteria. Ressearch has also linked poor gut health to many mental health conditions.

There are many things that impact the microbiome. Refined food commonly found in the typical Western diet, stress, alcohol, drugs, medications, hormones and many other things fosters the growth of this “bad” bacteria, causing inflammation and what we know as ‘dysbiosis’.

Dr Orr’s Microbiome Restore Protocol aims to reduce the intake of these refined foods and others things that impact the microbiome, and and instead foster the growth of “good” bacteria.

The Eating Plan

This eating plan is based on Dr Andrew Orr’s Primal Ancestral Clean Eating (PACE) diet.  It does allow quite a range of foods, so you shouldn’t have any trouble eating at home, or out anywhere. It is important to note that this is not a “diet.” This is simply the way we are supposed to eat.

2 Phase Microbiome Restore Protocol

Prior to starting the microbiome restore will also need to complete some health questionnaires and have a half hour consultation with Dr Andrew. The health questionnaire need to be fully completed and sent back prior to your consultation. All the relevant information will be supplied to you when you enquire, or book your consultation.

Alongside the PACE diet, this Microbiome Restore Protocol also involves supplementation that is set out in two phases. Both phases need to be completed in order to achieve working results.

Please note that the supplements prescribed as part of the microbiome restore protocol are practitioner only prescribed supplements which will require a consultation before they can be prescribed.

Phase 1 – Removal of Bad Bacteria & Gut Lining Repair

The first phase aims to restore the gut lining, remove bad bacteria and microbials, and create an environment in which good bacteria can thrive. Phase 1 will not need to be repeated (unless you wish you repeat the process in the future). It lasts for approximately 4 weeks, or until all of the products are finished. After that, you move on to phase 2 which then is also the maintenance phase.

Phase 2 – Replenishing the Microbiome & Good Gut Bacteria

After removing the bad bacteria, repairing the gut lining, and laying down a foundation for the good bacteria to grow, you will need to recolonise your gut with good bacteria. Strain specific bacteria are used and it will depending on the individual which probiotic strains are used.

Phase 2 aims to replenish the good gut bacteria through the use of Pre and Probiotics. This phase will be ongoing and used as maintenance for your condition. It is extremely important to continue your intake of Pre and Probiotics to ensure proper colonisation of good bacteria and restore on the microbiome.

Important Things To Note

It is important to note that the results of doing the microbiome restore could take months to come into effect and for there to be adequate good bacteria colonisation. It is likely that if you have been recommended to take part in this protocol, that your microbiome is quite compromised due to years of consistent damage. Because of this, it will likely take quite a while to properly restore the microbiome back to equilibrium. This is done by way of continuing with your prebiotics and strain specific healthy bacteria,  to get back on track and eventually feel healthier.

As mentioned previously, many things can impact gut bacteria including stress, alcohol, diet, etc. so it is important to be mindful of this and what you expose your body to on your pathway to recovery.

A good way to think of a damaged microbiome is like any other damaged organ or bone in the body. A broken bone, torn ligament, or damaged internal organ is not likely to heal overnight. It can take months or even years of recovery, rehabilitation or medicinal therapies to get on top of it. The same applies for your digestive tract. It is no exception to the rule in regards to healing time within your body. The best results come when people are consistent in sticking to their treatment plan, and are realistic about time frames and outcomes.

Next Step Is Book Your Consultation

If you need help with restoring your microbiome for better health, then please give my clinic staff a call and find out how my Microbiome Restore Protocol may be able to assist you on the pathway to better health. There are options for online, or in person consultations. Conditions may apply to online consultations.

For further information please call +61 07 38328369, or email info@drandreworr.com.au

References

  1. Walker A, et al. Phylogeny, culturing, and metagenomics of the human gut microbiota. Trends Microbiol. 2014;22:267–74.
  2. Collado MC, et al. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007;45(4):454-60.
  3. Leahy SC, et al. Getting better with bifidobacteria. J Appl Microbiol. 2005;98(6):1303-15.
  4. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16(18):2202-22.
  5. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  6. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  7. Dahan S, et al. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli induced signaling pathways in T84 cells. Infect Immun. 2003;71:766-773.
  8. Hsieh H. Versalovic J. The human microbiome and probiotics: Implications for pediatrics. Curr Probl Pediatr Adolesc Health Care. 2008;38(10):309–327.
  9. Lam EK, et al. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci. 2007;80(23):2128-36.
  10. Seth A, et al. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008;294(4):G1060-9.
  11. Gibson GR. Roberford M. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401-1412.
  12. Fastinger ND, et al. A novel resistant maltodextrin alters gastrointestinal tolerance factors, fecal characteristics, and fecal microbiota in healthy adult humans. J Am Coll Nutr. 2008;27(2):356-66.
  13. Raninen K, et al. Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose. Nutr Rev. 2011;69(1):9-21.
  14. Robison LE. Reeves S. EpiCor® and its immune effects on gut health. Embria Health Sciences, LLC. [Online]. No date. Available from: http://www.embriahealth.com/upload/pdf/EpiCor%20Science%20%20EpiCor%20and%20its%20Immune%20Effects%20on%20Gut%20Health_FINAL.pdf [Cited 16/02/13].
  15. Jensen GS, et al. Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food. 2011 Sep;14(9):1002-10.
  16. Bartoli, C., Frachon, L., Barret, M., Huard-Chauveau, C., Mayjonade, B., Zanchetta, C., … & Roux, F. (2018, May 30). In situ relationships between microbiota and potential pathobiota in Arabidopsis thaliana. The ISME Journal. Retrieved from https://www.nature.com/articles/s41396-018-0152-7#article-info
  17. Berg, R. D. (1996). The indigenous gastrointestinal microflora. Trends in Microbiology, 4(11), 430-435. Retrieved from https://www.sciencedirect.com/science/article/pii/0966842X96100573
  18. Carpenter, S. (2012, September). That gut feeling. Monitor on Psychology, 43(8), 50. Retrieved from http://www.apa.org/monitor/2012/09/gut-feeling.aspx
  19. Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017, September 15). Gut microbiota’s effect on mental health: The gut-brain axis. Clinics and Practice, 7(4), 987. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/
  20. NIH Human Microbiome Project. (n.d.). Retrieved from https://hmpdacc.org/
  21. Shepherd, E. S., DeLoache, W. C., Pruss, K. M., Whitaker, W. R., & Sonnenburg, J. L. (2018, May 9). An exclusive metabolic niche enables strain engraftment in the gut microbiota [abstract]. Nature, 557, 434-438. Retrieved from https://www.nature.com/articles/s41586-018-0092-4
  22. The Human Microbiome Project Consortium. (2012, 14 June). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. Retrieved from https://www.nature.com/articles/nature11234
  23. Ursell, L. K., Metcalf, L., K., Wegener Parfry, L., Knight, R. (2012, August). Defining the human microbiome. Nutrition Reviews, 70(Suppl 1), S38-S44. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426293/
Medications affecting the microbiome

Many Medications Significantly Affects The Microbiome

New research is emerging to show that many medications significantly affect the microbiome and lead to long term health implications through disruption of healthy gut bacteria.

As mention already in my previous post about the importance of proper restoring the microbiome for optimum health, many medications and hormones actually have a toxic affect on the microbiome and can cause dysbiosis. It is crucial to for all of us to understand the consequences of medication use in the gut microbiome. I’ll talk about this in my next post.

A new study has found that many common drugs — including those that treat diabetes, digestive problems, bacterial infections, and even depression — could actually predispose people to certain types of infection by affecting the balance of their gut microbiome.

New findings

A new study from the University Medical Centre Groningen and the Maastricht University Medical Centre, both in the Netherlands, has found evidence to suggest that many common drugs — from antibiotics to antidepressants — have a significant impact on the gut microbiome. They can even disrupt the delicate balance of bacterial populations.

The researchers compared the results of people who took prescription drugs with those of people who did not. They also looked at the effects of individual medications versus combinations of drugs.

They found that 18 common drug categories have a significant impact on the bacterial composition of the gut microbiome, which could lead to serious health issues. These health issues included intestinal infections, obesity, gastrointestinal conditions and various conditions linked to gut health.

Many Medications Disrupt The Microbiome

While pain medications, steroids, antidepressant and hormones (contraceptives and hormone replacement) were shown to significantly impact the bacterial balance in the microbiome, four drug categories appeared to have the strongest impact. These were:

  • Proton pump inhibitors (PPIs), which reduce the production of stomach acid
  • Metformin, which helps people manage the symptoms of type 2 diabetes
  • Antibiotics, which fight bacterial infections
  • Laxatives, which help treat constipation

The analyses revealed that people who took PPIs had more upper gastrointestinal tract dysbiotic bacteria, and that their bodies produced more fatty acid. Meanwhile, those who took metformin had higher levels of Escherichia coli, a bacteria that can cause diarrhoea and urinary tract infections. One of the reasons many stop Metformin is because of significant gastrointestinal symptoms and pain. Long term it can also damage the liver.

Antibiotics Significantly Impact The Microbiome

We have always know that antiobiotics have an major impact on the gut and microbiome, but many people are unaware that all medications have the potential to disrupt the microbiome and cause significant harm to our health long term.

When it comes to antibiotics, alarmingly Australians are amongst the highest users of antibiotics in the world with 46% of the population taking one course of antibiotics annually.

A single course of antibiotics can disrupt the gut microbiota quantity and composition for up to four years. The loss of microbial balance leads to a breakdown of endothelial barrier protection, increased intestinal permeability, and subsequent immune dysregulation.

Proper Microbiome restore needs to be done properly

As mentioned in my previous post, the good news is although a dysfunctional microbiome can come about rapidly, you can begin to restore a healthy microbiome just as quickly through strategic microbiome restore.

As I have said before, when it comes to proper microbiome restore,  it isn’t just as easy as taking any old probiotic, or a combination of probiotics. Microbiome restore requires and individualised and strain specific approach and it needs to be done in stages with antimicrobials, gut repair and prebiotics as well. Dysbiotic microbes can be hard to treat effectively because they have evolved and adapted to life inside human beings. Consequently, elimination of these organisms requires a similarly evolved and adapted approach. This is all part of the microbiome restore protocol I use with my patients.

If you would like to find out how to restore your microbiome properly, please give my friendly staff a call and find out how I may be able to assist you.

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate

 

Microbiome

The Importance Of Properly Restoring The Microbiome For Optimum Health

One of the things I teach my patients is the importance of properly restoring the microbiome for optimum health and also reducing inflammation in the body.

Many people’s daily bloating, fluid retention, gastrointestinal symptoms, health issues, chronic disease states are being exacerbated by an unhealthy balance in this unique ecosystem we call the microbiome.

The problem is that many people do not really understand the importance of the microbiome, and even many healthcare professionals do not fully understand how to help with proper microbiome repair and restore.

Many people are also led to believe that by just taking probiotics, that this is enough to restore the healthy bacteria in the gut/microbiome.

I wish it was that easy, but it isn’t and this is why many people continue to have gastrointestinal issues, inflammation and chronic health issues, despite thinking that are doing the right thing for their gut health.

What is the Microbiome?

The human gastrointestinal tract (GIT) is host to an extraordinary amount of microorganisms composed of bacteria, viruses and microbes, collectively known as the microbiome. The microbiome is the name given to all of the genes inside these microbial cells.

Every human being has anywhere between 10 trillion and 100 trillion microbial cells all working together in a symbiotic relationship. This benefits both the microbes and their hosts, as long as the body is in a healthy state.

Recent scientific advances in genetics mean that humans know a lot more about the microbes in the body. There has been lot of time and money put into researching the interactions within the human body’s ecosystem and their relevance to health and disease.

The two terms ‘microbiota’ and ‘microbiome’ are often used to mean the same thing and are used interchangeably. I will explain the differences between them and how both are being used and researched in modern medicine.

You exist in a symbiotic relationship with your bacterial ecosystem, and there is a two-way relationship that makes your health inseparable from that of your microbiome and vice versa.

The benefits of a healthy microbiome/microbiota

The benefits of a healthy microbiome/microbiota, extend beyond the gut and digestive system and has a significant systemic impact on some the following:

  • Nutrient metabolism
  • Body composition (weight)
  • Cardiovascular health,
  • Chronic disease states
  • Inflammation in the body
  • Pain pathways
  • Immunity
  • Mental Health
  • Neuroendocrine function
  • Gene Expression

What is the Microbiota

The gut microbiota used to be called the microflora of the gut. The importance of the microbiota has been known for a long time, but now medical science is discovering just how important it is, and it is now becoming a cornerstone of preventive medicine.

The gut microbiota contains over 3 million genes, making it 150 times more genetically varied than the human body. The gut microbiota of each individual is very unique and it has a major contribution to how a person fights disease, digests food, and even his or her mood and psychological processes.

This symbiotic relationship greatly benefits humans. The presence of this normal flora includes microorganisms that are so present in the environment that they can be found in practically all animals from the same habitat.

However, while there are good bacteria found within these native microbes, some of these microbes also include harmful bacteria that can overcome the body’s defences that separate them from vital systems and organs. There are beneficial bacteria in the gut, and there are harmful bacteria that can cross into wider systems and can cause local infections of the GI tract. These infections can then cause infection and inflammation and can also worsen disease states in the body.

What is dybiosis?

The microbiome plays an important role in resisting intestinal overgrowth of externally introduced populations that would otherwise cause disease. In our microbiome, the “good” bacteria compete with the “bad,” with some even releasing anti-inflammatory compounds.

Bacterial dysbiosis produces an endotoxin called lipopolysaccharide (LPS). It is one of the most inflammatory substances known. LPS is also major contributor to the inflammation, which then drives many chronic health conditions and disease states.

These bad bacteria are called dysbiotic bacteria and cause a process called ‘dysbiosis’.

Broadly speaking, dysbiosis indicates the existence of either the wrong microbiota (e.g. overgrowth of bacteria, fungi and/or parasites) and/or the wrong numbers of the right microbiota (imbalances in composition), or either, in the wrong place.

Dysbiosis causes increased gut and intestinal permeability, which can lead to what we call leaky gut, or leaky gut syndrome. Dysbiosis can also consequent lead to up-regulation of inflammatory pathways and lead to increased inflammation in the body.

Dybiosis is implicated in many chronic diseases

Dysbiosis is very common it the western culture and bacterial dysbiosis is now being linked to causing, or exacerbating many health conditions and disease states. Research has found links between bacterial populations, whether normal or disturbed, and the following diseases:

  • Endometriosis
  • Adenomyosis
  • PCOS
  • Asthma
  • Autism
  • Auto-immune conditions
  • Cancer
  • Celiac disease
  • Colitis
  • Inflammatory Bowel Disease
  • IBS
  • Crohn’s Disease
  • Diabetes
  • Eczema
  • Heart disease
  • Malnutrition
  • Multiple sclerosis
  • Arthritis
  • Obesity
  • Metabolic Syndrome

What Causes Dysbiosis?

There are many things that lead to bacterial overgrowth, which then leads to dysbiosis. This is why many people suffer bloating, reflux, nausea, constipation, inflammatory bowel symptoms, and many other gastrointestinal symptoms daily.

Day-to-day risk factors include a western-based diet, overly hygienic living (being too sterile), alcohol, certain medications, hormones and the use of antibiotics.

Mood disorders, stress and being overly busy are also a big factors with creating dysbiosis and something that many overlook, or do not even realise. Yes, stress is a big factor in many gastrointestinal symptoms people experience daily.

With all these factors it means that almost everyone will have some degree of dysbiosis at some point in their life.

Many constantly have dysbiosis and why they often have long-standing digestive symptoms such persistent pain and bloating, constipation, alternating diarrhoea or other digestive imbalances. We also commonly see this with endometriosis and the dreaded “endo belly”

Medications Cause Dysbiosis and Significantly Affect The Microbiome

As mention already, many medications and hormones actually have a toxic affect on the microbiome and can cause dysbiosis. It is crucial to for all of us to understand the consequences of medication use in the gut microbiome. I’ll talk about this in my next post.

The good news, however, is although medications can cause a dysfunctional microbiome quite rapidly, you can begin to restore a healthy microbiome just as quickly through strategic microbiome restore.

Proper Microbiome Restore Protocols

When it comes to proper microbiome restore,  it isn’t just as easy as taking any old probiotic, or a combination of probiotics. Microbiome restore requires and individualised and strain specific approach and it needs to be done in stages with antimicrobials, gut repair and prebiotics as well. Dysbiotic microbes can be hard to treat effectively because they have evolved and adapted to life inside human beings. Consequently, elimination of these organisms requires a similarly evolved and adapted approach. This is all part of the microbiome restore protocol I use with my patients.

A New Understanding

When it comes to the perfect microbiome, researchers have discovered there is no ‘one size fits all’ across various populations. It is important to recognise that not all strains are created equal when it comes to their ability to rebuild a healthy microbiome.

What is now known is that there are only certain types of good probiotic bacteria that have benefit for our gut and microbiome, and that some strains of probiotic bacteria have no benefit. These new finding mean that we need to adopt a strain specific approach when repairing and restoring the microbiome.

From recent investigations and research, the best results are gained by introducing strain specific influential probiotic that have beneficial functions. These specifically influential strains are able to restore each patient’s unique microbiome by promoting the growth of key commensal (symbiotic) groups, but also by improving overall GIT function.

The Importance of Prebiotics

In addition to prescribing a specific probiotic formulation, prebiotic therapy is needed to help support and encourage the establishment of healthy microbiota by significantly increasing the numbers of beneficial bacteria. Without prebiotics, the probiotic bacteria do not grow and this is why they are essential for microbiome restore. Prebiotics are not talked about enough and many people do not realise their importance and often wonder why their probiotics are not working effectively enough.

Prebiotics are also needed to promote the growth of healthy microbiota, begin refurbishment of gut mucosa and improve gastrointestinal immunity. Prebiotics also help with inflammation and also support the integrity of the intestinal barrier, provide healthy immune responses and promote intestinal microbiome balance.

Microbiome Restore Protocols

With emerging research now highlighting the significance of developing and maintaining a healthy microbiome, it is important that everyone knows the importance of appropriate probiotic and prebiotic combinations. By supporting the restoration and repair of our micriobiome, we can all optimise our health, improve treatment outcomes and also help with reducing the risk of many chronic disease states.

If you would like to find out how to restore your microbiome properly, please give my friendly staff a call and find out how I may be able to assist you. Online and in person consultations are available. Some conditions apply.

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate

References
  1. Walker A, et al. Phylogeny, culturing, and metagenomics of the human gut microbiota. Trends Microbiol. 2014;22:267–74.
  2. Collado MC, et al. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007;45(4):454-60.
  3. Leahy SC, et al. Getting better with bifidobacteria. J Appl Microbiol. 2005;98(6):1303-15.
  4. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16(18):2202-22.
  5. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  6. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  7. Dahan S, et al. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli induced signaling pathways in T84 cells. Infect Immun. 2003;71:766-773.
  8. Hsieh H. Versalovic J. The human microbiome and probiotics: Implications for pediatrics. Curr Probl Pediatr Adolesc Health Care. 2008;38(10):309–327.
  9. Lam EK, et al. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci. 2007;80(23):2128-36.
  10. Seth A, et al. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008;294(4):G1060-9.
  11. Gibson GR. Roberford M. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401-1412.
  12. Fastinger ND, et al. A novel resistant maltodextrin alters gastrointestinal tolerance factors, fecal characteristics, and fecal microbiota in healthy adult humans. J Am Coll Nutr. 2008;27(2):356-66.
  13. Raninen K, et al. Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose. Nutr Rev. 2011;69(1):9-21.
  14. Robison LE. Reeves S. EpiCor® and its immune effects on gut health. Embria Health Sciences, LLC. [Online]. No date. Available from: http://www.embriahealth.com/upload/pdf/EpiCor%20Science%20%20EpiCor%20and%20its%20Immune%20Effects%20on%20Gut%20Health_FINAL.pdf [Cited 16/02/13].
  15. Jensen GS, et al. Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food. 2011 Sep;14(9):1002-10.
  1. Bartoli, C., Frachon, L., Barret, M., Huard-Chauveau, C., Mayjonade, B., Zanchetta, C., … & Roux, F. (2018, May 30). In situ relationships between microbiota and potential pathobiota in Arabidopsis thaliana. The ISME Journal. Retrieved from https://www.nature.com/articles/s41396-018-0152-7#article-info
  2. Berg, R. D. (1996). The indigenous gastrointestinal microflora. Trends in Microbiology, 4(11), 430-435. Retrieved from https://www.sciencedirect.com/science/article/pii/0966842X96100573
  3. Carpenter, S. (2012, September). That gut feeling. Monitor on Psychology, 43(8), 50. Retrieved from http://www.apa.org/monitor/2012/09/gut-feeling.aspx
  4. Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017, September 15). Gut microbiota’s effect on mental health: The gut-brain axis. Clinics and Practice, 7(4), 987. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/
  5. NIH Human Microbiome Project. (n.d.). Retrieved from https://hmpdacc.org/
  6. Shepherd, E. S., DeLoache, W. C., Pruss, K. M., Whitaker, W. R., & Sonnenburg, J. L. (2018, May 9). An exclusive metabolic niche enables strain engraftment in the gut microbiota [abstract]. Nature, 557, 434-438. Retrieved from https://www.nature.com/articles/s41586-018-0092-4
  7. The Human Microbiome Project Consortium. (2012, 14 June). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. Retrieved from https://www.nature.com/articles/nature11234
  8. Ursell, L. K., Metcalf, L., K., Wegener Parfry, L., Knight, R. (2012, August). Defining the human microbiome. Nutrition Reviews, 70(Suppl 1), S38-S44. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426293/
angry anxiety brunette 2128817

Acupuncture Is Safe & Effective For The Relief of Migraines.

Researchers have successfully documented not only that acupuncture is safe and effective for the relief of migraines, but also how acupuncture achieves positive outcomes.

As a past sufferer (yes past sufferer) of Migraines, I know all too well how debilitating and painful this condition can be when an attack happens. Even when the initial stage of the Migraine subsides, the aura and residual effects can last for days. While pain medication is a much needed part of the process, I also know that if you don’t administer the medication at the right time, the medication sometimes will have little, or no effect, once the migraine takes hold. Worse still, the withdrawal effects of these very strong pain medications can often then induce migraines and headaches, which then require further medication. It really can be a never-ending viscous cycle.

Migraines really do need a multimodality approach to them because the causes of them come from neck dysfunction(sublaxations), diet, blood sugars, hormones, stress and lifestyle. This is why an individual approach is always needed to properly assess, evaluate and treat migraines is needed. Too many people are just patching their condition, with a variety of treatments that really are only just getting them through to the next attack. What people need is a treatment that will not only treat the cause of their migraines, but also help prevent further migraines and give them long term relief and even cure. Acupuncture is just one component in that overall treatment and prevention, alongside medical interventions. So let’s look at how acupuncture can help.

How can Acupuncture Help?

Acupuncture has been shown to induce important biological responses to prevent and alleviate migraines. Imaging studies of the brain using fMRI technology confirm that acupuncture causes specific cortical responses to achieve lasting analgesic effects. In addition, blood level measurements document specific responses to acupuncture that play an important role in preventing and eliminating pain.

Researchers conclude that acupuncture is effective for the prevention and treatment of migraine headaches. A meta-analysis of controlled clinical and laboratory investigations are the basis for the conclusion. In analysis of recent clinical trials, they showed the effectiveness of acupuncture as a treatment for migraines, with less migraine days and less pain intensity levels when acupuncture was administered. Furthermore, no severe adverse effects occurred. A follow-up of up to three months following acupuncture treatments maintained the same results and showed that acupuncture is effective for the treatment of migraines both on the short-term and long-term basis.

In some of the investigation, researchers conducting a clinically-controlled study using fMRI (functional magnetic resonance imaging) where they found a significant decrease in the functional connectivity of the right frontoparietal network of migraine patients. This connectivity dysfunctions was found to be reversible after four weeks of treatment using acupuncture. This is another curative effect of acupuncture that is quantifiable in repeated controlled experiments.

Acupuncture has been used for assistance with pain for centuries

For over 7 thousand years, people have used acupuncture in China for the treatment of various pain conditions, including migraines. It is useful, both as a supplementary treatment and as an alternative treatment, in situations where there is no response to drug therapy. Migraines are a headache disorder affecting a broad population that causes many burdens due to associated healthcare costs and people not being able to go to school and work.

Up to 25% of households in Australia and the United States have at least one member who suffers from migraines. The estimated total number of migraine patients in the United States alone exceeds 28 million and half of them have reduced work or school productivity. In Australia millions of people suffer from Migraines daily and it also affects their work, study and general day to day function, with some not even able to leave their homes due to this debilitating condition.

Acupuncture has an analgesic action

Scientists have uncovered some of the biochemical mechanisms responsible for acupuncture’s pain killing effects. Drugs used for the treatment of migraines not only have a analgesic action, but they also activate a reaction in the cerebral vessels. In the studies analyzed it was found that acupuncture has been found this very same analgesic action and also activated the same process in the cerebral vessels. The studies revealed acupuncture’s ability to regulate key regions of the brain affected by migraines. The areas are essentially the pain circuitry regions of the brain and cognitive components of pain processing. In addition, acupuncture also restores normal serum nitric oxide (NO) levels that have been found to be almost 55% higher in patients with migraines. Excess NO is a potent vasodilator contributing to headaches and acupuncture restores homeostasis. The regulatory effects of acupuncture can be quantified as early as the fifth acupuncture session and the effects are cumulative.

Based on these and other studies in the meta-analysis, the researchers conclude that acupuncture improves patients’ psychological profile, relieves pain, is safe and cost-effective, and has been found to be at least as effective as conventional preventative pharmacologic treatments for migraines.

Final Word

At my clinic we know we see lots of people who are looking for relief from headaches and migraines. We use a multimodaility approach that also give an individualized treatment and also looks at the individuals cause of their migraines and headaches. Our aim is to assist in the with acute symptoms of migraines and headaches and assist in the prevention of them as well, along side medical interventions. With the right care, this can be done and now research is now backing up what we have known for many years.

If you need help with headaches and migraines, please call my friendly staff and find out how I may me able to assist you in your individual needs and ongoing health care.

Regards

Andrew Orr

-No Stone Left Unturned

-The Headache, Migraine and Pain Experts

 

References:

  1. Wang Y, Xue CC, Helme R, Da Costa C, Zheng Z (2015) Acupuncture for Frequent Migraine: A Randomized, Patient/Assessor Blinded, Controlled Trial with One-Year Follow-Up. Evid based Complement Alternat Med 2015: 920353.
  2. Da Silva AN (2015) Acupuncture for migraine prevention. Headache 55: 470-473.
  3. Vijayalakshmi I, Sjankar N, Saxena A, Bhatia MS (2014) Coomparison of effectiveness of acupuncture therapy and conventional drug therapy on psychological profile of migraine patients. Indian J Physiol Pharmacol 58: 69-76.
  4. Mayrink WC, Garcia JBS, Dos Santos AM, Nunes JKVRS, Mendonc¸a THN. Effectiveness of Acupuncture as AuxiliaryTreatment for Chronic Headache. J Acupunct Meridian Stud 2018 Oct;11(5):296e302.
Fertility and Google

Fertility- “When your google search is just not going to cut it”

I always have a little bit of a chuckle to myself when people call my clinic and try to tell my staff that they know everything there is to know about fertility and that they don’t need to have any other investigations etc, because they have had them all done.

Then when I check, not only have they not had them all done, but the person actually only knows the bare basics about fertility. It is perception versus reality and a degree is doctor google, does not make one an expert.  I often have to say to these people that if they really did know everything, then why aren’t they falling pregnant, the truth is generally a reason why.

The truth is, there is generally a reason why, and it is because they don’t know and they actually need help from someone who does not, and someone who is an expert in reproduction.

There is no easy way when it comes to fertility

I wish it was that easy, because that way I would not have had to study to obtain a Master Degree in Reproductive Medicine, done countless hours of clinical research, and  done hands on experience over the last 20 or more years to know what I know now.

The truth is, unless you are a fertility specialist, have extra post graduate training in fertility, and actually work in the field of fertility and reproduction, you just cannot know all there is to know about fertility. It would be like me doing a google search on astrophysics, or any other field I am not qualified in, and then saying that I am now an expert because I have done a few google searches.  We really need to put all of this into perspective and be real about this. I am all for people being educated, but really, you cannot be an expert without years of study, training, ongoing research and hands on experience.

Doctor Google does not have all the answers

I also know that not everyone in the fertility profession is well qualified either and this is due to the lack of regulation in this profession. But, even so, you cannot just do a google search, or do a few IVF cycles, or get advice from some support page, and then call yourself and expert.  Just remember that a lot of the information on Dr Google is actually wrong, or only partially true and that support groups often contain members of the general public, who have no medical experience what so ever. Yet these days, many are taking the medical advice given on these pages and that is absolutely dangerous. I don’t mean for this to sound harsh, because support groups are a great thing, but we need to be real about who and where we get our medical advice from, especially when it comes to fertility.

Fertility is complex with multiple variants

Fertility is not just about putting and egg and a sperm together and it just works. Let’s be real about this. Making a baby is not as easy as our parents and teachers used to tell us. There is a science behind it and it requires the right timing the right conditions and also optimum health of the parents physically, mentally and also genetically.

Age is one of the biggest factors with fertility

Age is also a huge factor. The older we are, the more issues we have with sperm and eggs and the more random genetic and chromosomal errors we get with embryos.

Genetics is very important when it comes to fertility

Genetics is also something many do not understand and something that many overlook. At present I test couples for 180 different genetic mutations , genetic variants and genetic issues that could be affecting a couples chances of pregnancy.

Not to mention Karyotyping to see if the couple is in fact male and female, or don’t have translocation issues on their X & Y chromosome, or other genetic issues such Turners syndrome, Kleinfelters syndrome etc. Then there is cystic fibrosis screening and many other genetic screenings that most people have never had tested and without proper training would not be able to understand how to interpret them either.

Assisted Reproduction

Then we have IVF and Assisted reproduction, which is not as simple as giving someone some hormones, and putting a sperm and an egg together. I wish it was that simple. There are many variants with the whole IVF process that the general public just do not understand and if you don’t know what these are, things can go wrong very quickly. Let’s face it, if you don’t get hormones and everything right, women have died on IVF cycles, or become very critically ill in the process.

The science of embryology takes years of study

We also have scientists who have done years of study to understand embryology and the very intricate details of what it takes to create an embryo. Even when an embryo is created, it does not mean it will go on to become a baby and there are many reasons behind this. This sort of stuff the general public just do not understand and cannot understand with a mere google search.

When an embryo is created, it is then a mixture on egg, sperm and all the chromosomal and genetic variants from the male and female. Many things can go wrong. There can be random errors, there can be arresting of the embryo growth process and then there are also nutrients and so many other factors that are needed for an embryo to just making it to day 5 ( which is called a blastocyst). That is if it actually makes it that far, which many don’t. Regardless of the classification system and grading system for embryos, it does not mean that the embryo is chromosomally viable, nor does it mean it will go on to become a baby.

Sometimes science cannot explain everything

Some technology surrounding embryo quality and viability we just do not have yet.  So in essence, one an embryo is formed; it compacts and grows, and then makes it to transfer. What happens after this really is up to chance. Sure, there is a science behind it all, and that science is very intricate and precise, but there is also an element that is “left up to the gods”, so to speak

The same actually goes for natural conception too. It is exactly the same processes really, except it is all done in the body. The only difference is that we do not know if the sperm and egg are actually meeting and forming an embryo month after month. It is a waiting game to see what happens just the same as it is for those doing IVF who also have to wait to see if a transfer is successful.

You need a real degree, not a google degree to understand reproduction fully

There is so much to fertility and conception that many will never be able to comprehend, unless they undertake the study to do so. Even then you need to be doing the actual hands on work on this profession too. There is a huge difference between what one reads in a text book, to what actually happens in practice. It is a marriage of theory, study, research and practical experience that is needed to actually call one an expert in reproduction and fertility.

Education is important, but be careful who your source is

When I say all this, this is not to discourage people from being educated, asking questions and finding out as much as they can on their journey to become parents. Education is important and this is why I do my fertility program, so that couples are educated on everything they need to know about fertility and what is needed to have a baby.

My fertility program covers what no google search every will

In my fertility program and education for couples,  I go through everything from medical procedures, genetics, pathology, chromosomes, egg quality, sperm quality, male and female health, gynaecological issues, male fertility issues, surgical interventions, counselling, supplements, dietary and lifestyle changes, diet plans, IVF and assisted reproduction, hormones, medications, complementary medicines, scientific procedures (andrology, embryology, ICSI etc) and so much more that can only be given to couples by multiple degrees, post graduate degrees in Reproductive medicine, and over 20 years’ experience in helping couples have babies.

The importance of seeing a reproductive medicine expert

As I have tried to explain, there really many things that are needed to ensure optimum fertility and better chances of a successful pregnancy outcome. I wish it was as easy as doing a google search and that all answers could be provided. There are lots of underlying reasons that couples are not falling pregnant and this is why it is important to see someone who knows what they are talking about and who is an expert in reproductive medicine. They also need to be appropriately qualified and certified, because the fertility profession is largely unregulated. Like any profession, there are lots of bad practitioners out there too. This is in both the medical and complementary medicine.

Do you your homework, but don’t rely on google

Do your homework on whom you are thinking about going to see, but please remember that your google search does not make you an expert. Google does not have all the answers when it come to the very complex and intricate details of the world of fertility and reproduction. Please see someone who is trained properly, who has years of experience, who is caring, who does listen, and who can guide you through every step of the process in your journey to having a baby.

Final word about fertility and reproduction

Last but not least, when it comes to treating a couple for fertility, both the male and female need to be investigated and managed as part of legal and ethical requirement for fertility services. We cannot just see the female as males are 50% of the fertility equation. If a male is not on board, then females need to be asking some big questions of their partner, not the fertility clinics they are trying to go to. Biology 101 tells us that it takes a sperm and egg to make a baby, and not just an egg and this is something that I talk about often.

If you do need help and assistance with having a baby, and need to find out all the proper information and answers regarding reproduction, please give my friendly staff a call and enquire how I may be able to assist you in your journey to becoming parents as part of my fertility program.

Regards

Andrew Orr

-No Stone Left Unturned

-Master of Reproductive Medicine

-The International Fertility Experts

Fertility Facts Ovulation does not occur mid cycle for every woman.

Ovulation Does Not Occur Mid-Cycle For Every Woman

Ovulation can happen at anytime in a cycle and research has shown that more than 70% of women are ovulating outside the traditional view that ovulation occurs mid-cycle.

Too many couples are focussing on this small window period, when in fact ovulation may be occurring before, or after.

Many are also unaware of when they are actually ovulating and some women may in fact not be ovulating at all. This is why it is important to find out by proper monitoring by a trained professional.

Once an egg is release it has but 24 hours to be fertilised, otherwise it will die.

The egg also needs one vital ingredient during this time…… sperm. This is why men need to be evaluated properly, to see that their swimmers can actually swim and fertilise the egg.

This is why couples need to be trying to have sex as much as possible when trying to conceive. Miss having sex in that 24 hours period and then there is no chance until the next cycle.

If you are trying for a baby and not having any success, then it is time to get some real help and some proper evaluations and management around your fertility.

My Fertility Program has helped over 12,500 (plus) babies into the world and it could be the answer to assisting you having your baby as well.

For more information and to book in for the program, please contact my friendly staff on +61 07 38328369, or email info@drandreworr.com.au, or contact by the online form on the website.

You can also book a meet and greet appointment prior to joining the program (to find out more information) and we do see couples locally, interstate and from overseas.

Copy of Fertility Facts Being Overweight or underweight can adversely affect fertility

Being Overweight, or Underweight Can Adversely Affect Fertility

It is important to have healthy weight and waist size when trying to conceive. It is know that being underweight, or underweight can adversely affect fertility.

Healthy Waist Size

Healthy waist range for a woman is 80cm (from the belly button around) Healthy waist range for a man is 94cm (from the belly button around)

If a woman’s waist size is about 88cm and a man’s waist size if above 102cm then they are in what we call “metabolic syndrome”

Metabolic Syndrome

Metabolic syndrome increases their chances of the following:

  • diabetes
  • heart disease
  • depression
  • gynaecological conditions (PCOS, endometriosis etc)
  • sperm issues,
  • egg quality issues
  • reproductive issues,
  • increased miscarriage
  • increased risk of certain cancers
  • infertility

Excess body fat (now known as obestrogens) can disrupt hormones and fertility and can have a negative effect on egg and sperm quality.

Similarly being underweight and low body fat can affect fertility outcomes too.

Body fat has a regulatory role in reproduction

Body fat has a regulatory role in reproduction and a moderate loss of fat, from 10% to 15% below normal weight for height, may delay the menstrual cycle, completely stop the menses altogether and inhibit ovulation. Both dieting and excessive exercise can reduce body fat below the minimum amount and lead to infertility. But this is reversible with weight gain, increased body fat and reduction of intensive exercise, or both.

A moderate reduction in body fat, not just weight, for those overweight, can increase fertility and chances of pregnancy exponentially.

Similarly an increase in body fat for those that are underweight, and who don’t have enough body fat, can increase their fertility and chances of pregnancy as well.

This goes for men too. Increased body fat, or not enough body fat can affect hormone production and fertility and can affect sperm quality and sperm production.

The importance of preconception care

This is why preconception care and healthy screening and weight and waist management is so important before trying to conceive. This should also be a part of any fertility program and is definitely part of my fertility program for all couples.

Are you in healthy waist range?

Regards

Andrew Orr

– No Stone Left Unturned

-Master of Reproductive Medicine

-The International Fertility Experts

Metformin for ovarian cancer

Could A Diabetes Medication Prevent Ovarian Cancer?

A laboratory study published in Clinical Cancer Research offers a new hypothesis about how ovarian cancer forms and suggests how an insulin resistance/diabetes medicine may prevent it.

Ovarian Cancer Facts.

  • Ovarian cancer is the fifth most common cancer in women, and
  • Ovarian cancer is a leading cause of cancer death in women
  • The five-year survival rate for ovarian cancer is 45 percent.
  • Women who have a family history of ovarian cancer or a mutation of the BRCA gene are at greatest risk of the disease.
  • There is no reliable screening test to catch this cancer early
  • The only options for prevention are birth control pills, which reduce the risk of ovarian cancer by half, or removing the ovaries and fallopian tubes.
  • Common symptoms are bloating, abdominal pain, gastrointestinal upset and weight loss/gain.

For more information on Ovarian Cancer please click the link to my article Let’s Talk About Ovarian Cancer

The New Research.

The study is the first to show that the natural stiffening of the ovaries called “fibrosis” occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

This is an interesting hypothesis, which then begs many questions. It also then leads to looking at other supplements and medications that help with insulin resistance and regulation.

So, should we just be looking at the medications, or looking at the underlying cause of the issue, which seems to be insulin resistance?

After all, insulin resistance is a big driver on inflammation and disease processes in the body. But let’s look at Fibrosis first.

What is Fibrosis?

Fibrosis happens when body tissues are repeatedly injured and inflamed, leaving behind hard collagen fibres that pile up over time, like a scar on the skin. Research has shown that cancer cells tend to like growing in these fibrotic tissues. Fibrosis is also a normal part of aging and usually appears around the menopausal stage of life.

The Findings of The Study

The first part of the investigation was for the team to find out what was causing the fibrosis of the ovaries. They thought the answer might lie in ovulation. Every time an ovary releases an egg it becomes inflamed, creating a monthly cycle of wound and repair.

During the study the research was surprised to find an ovary from a 69-year-old woman that had no fibrosis. The woman’s medical records showed she had been taking metformin, a drug for Type 2 diabetes. What was interesting is that a Taiwanese study had previously noted an 82% reduction of ovarian cancer rates among Type 2 diabetes patients taking metformin.

The research team performed a series of experiments to investigate the links between ovarian fibrosis, aging and metformin.

The first part of the research, the team used mice studies and used a drug to prevent mice from ovulating. They noticed that the treated mice did not develop fibrosis with age, which then suggested that ovulation might be linked to the development of fibrosis. The team also noted that more detailed studies are needed to confirm these findings.

The second part of the research was to examine the ovaries that had been removed from women of all ages. What they found was that the ovaries of most of the postmenopausal women had fibrosis. But, they also notices the when the ovaries of postmenopausal women where were taking metformin were examined, none of these showed any evidence of fibrosis.

With these new finding the team set about looking at the rationale of targeting ovarian fibrosis as new option to reduce the risk of ovarian cancer. They also added in the rationale for the use of metformin to prevent ovarian cancer, based on these findings as well. The team are currently doing more research into learning how fibrosis develops in the ovaries and how metformin may be stopping this from happening.

These findings will need to be confirmed with more studies before clinical trails can take place. But, this could lead to a non-invasive test to measure fibrosis and help with early detection of ovarian cancer.

The team are hoping that metformin may prove to be an effective preventative treatment for younger women who are at high risk of ovarian cancer, but who can’t remove their ovaries because they still want to have children.

Added thoughts

While any research into ovarian cancer is welcomed, as mentioned previously, if metformin is helping with prevention of fibrosis, then surely we need to be looking insulin resistance as being a major cause of this?

It also begs the question, do other natural insulin regulators such as inositol do the same thing and would be better to use because Metformin does have a high side effect profile?

Insulin Resistance and Disease

We do know that insulin is a big driver of inflammation and disease states in the body. Insulin resistance is the name given to when cells of the body don’t respond properly to the hormone insulin.

Insulin resistance is the driving factor that leads to many disease states and health conditions such as:

  • Obesity and being overweight
  • Metabolic Syndrome
  • Type 2 diabetes,
  • Gestational diabetes
  • Pre-diabetes.
  • Stroke
  • Cardiovascular disease
  • Stroke
  • PCOS
  • Reproductive conditions
  • Infertility

Insulin Resistance is linked to certain cancers

Meanwhile, insulin resistance and metabolic syndrome are also linked with higher risk for cancers of the bladder, breast, colon, cervix, pancreas, prostate and uterus. 

The connection: High insulin levels early in insulin resistance seem to fuel the growth of tumours and to suppress the body’s ability to protect itself by killing off malignant cells.

Insulin resistance is closely associated with obesity; however, it is possible to be insulin resistant without being overweight or obese. We see this in women who have PCOS and who are not overweight, or obese.

Modern research has shown that insulin resistance can be combatted by treatment methods that reduce how much insulin the body is producing. Reducing insulin resistance can be achieved by following a grain free, low refined food diet.

Final note

If found to metformin to helping with fibrosis and this then leads to ovarian cancer, surely we need to look at what the root cause it. As mentioned above, one could assume it would have to be insulin resistance and we already know that insulin resistance is a driver of certain cancers and tumours.

Surely then, it would make sense to educate women, especially those with family history of ovarian cancer, about the importance of low GI diets and maintaining optimum health and optimum weight etc, in the prevention of not only ovarian cancer, but other disease states that affect women as well.

There are also valid alternatives to using Metformin, which has a very high side effect profile and has some long-term health consequences. There are valid alternatives such as using inositol, which has lots of research behind it and has been compared to Metformin in several research studies. Something to think about and I always like to give people something to think about important issues such as this. Just remember that you heard it here first.

 

Journal References:

  1. Curtis W. McCloskey, David P. Cook, Brendan S. Kelly, Feryel Azzi, Christian H. Allen, Amanda Forsyth6, Jeremy Upham, Katey J. Rayner, Douglas A. Gray, Robert W. Boyd, Sangeeta Murugkar, Bryan Lo, Dominique Trudel, Mary K. Senterman, Barbara C. Vanderhyden. Metformin abrogates age-associated ovarian fibrosisClinical Cancer Research, Oct 9, 2019
  2. Mehri Jamilian; Pegah Farhat; Fatemeh Foroozanfard; Faraneh Afshar Ebrahimi; Esmat Aghadavod; Fereshteh Bahmani; Bita Badehnoosh; Hamidreza Jamilian; Zatollah Asemi. Comparison of Myo-inositol and Metformin on Clinical, Metabolic and Genetic Parameters in Polycystic Ovary Syndrome. A Randomized Controlled Clinical TrialClin Endocrinol. 2017;87(2):194-200.
  3. Fruzzetti F, Perini D, Russo M, et al. Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2017;33:39–42.
  4. Chiu TT, Rogers MS, Law EL, et al. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod. 2002;17:1591–1596.
  5. Artini PG, Di Berardino OM, Papini F, et al. Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study. Gynecol Endocrinol. 2013;29:375–379.
  6. Zacche MM, Caputo L, Filippis S, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508–513.
  7. Costantino D, Minozzi G, Minozzi E, et al. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009;13:105–110.
  8. Orgel: The Links Between Insulin Resistance, Diabetes, and Cancer. Curr Diab Rep. 2013 Apr; 13(2): 213–222. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/
  9. Dijiogue S: Insulin resistance and cancer: the role of insulin and IGFs. Endocr Relat Cancer February 1, 2013 20 R1-R17. http://erc.endocrinology-journals.org/content/20/1/R1.full
  10. Orgel: The Links Between Insulin Resistance, Diabetes, and Cancer. Curr Diab Rep. 2013 Apr; 13(2): 213–222. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/

 

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Lycopene Helps Improve Sperm Quality

A new research study conducted by the university of Sheffield has shown that supplementation of Lycopene, a compound found in cooked tomatoes, has helped improve the sperm quality in a group of men.

Many studies have examined the role of dietary factors, antioxidants and amino acids and data from randomized controlled trials suggest that antioxidant therapy can improve sperm quality.

Health benefits of lycopene supplementation have been proposed for a variety of health conditions. This recent study examines whether 14mg of daily lycopene supplementation, for 12 weeks, can help improve sperm motility and sperm morphology in men.

Poor sperm quality

Poor sperm quality is a major contributor to infertility in heterosexual couples, but men are often overlooked and often are unwilling participants in the journey to have a baby. There is no doubt that sperm quality is declining and many couples inability to have a baby is actually coming from the male side of things, not the female side.

It is generally recognized that 50% of fertility issues are related to male sub-fertility and poor quality sperm. Typically, fertility problems in the male manifest themselves as ejaculates containing too few sperm (oligozoospermia), or sperm that swim poorly (asthenozoospermia), or sperm with poor size and shape (teratozoospermia) or a combination of all three.

Factors Affects Sperm Quality

Known factors that affect sperm are – Poor diet, obesity, alcohol, smoking, recreational drugs, steroids, medications, chemicals and environmental factors. There are also genetic and hereditary issues that affect sperm as well.

Women are often driving force behind fertility health

Women are often the ones being very proactive in whatever it takes to have a baby and will take supplements, improve their diet, and look at any way they can to help with conceiving. Unfortunately, getting men to do the same can be like pulling teeth and we need to start educating men of the importance of preconception care prior to having a baby.

Men offered very little advice about sperm health

Unfortunately many fertility clinics and healthcare practitioners in general, are giving very little advice and information around what men can do to improve their sperm. Many healthcare professionals are also only focussing on delivering general advice to highlight the known lifestyle risks for poor sperm quality. More advice around preconception care is needed.

Preconception care for men is a must

There is now lots of research about the importance of preconception care for men and lots of research on the importance of a healthy diet, lifestyle changes and the role of antioxidants and amino acids for sperm health and sperm quality.

This recent study could add to the ways that men can improve their sperm quality and help with the outlook for men with known sperm issues. This recent study could also add to existing research and could also lead to better ways to reduce the damaging impact of modern living on reproductive health. We really do need for all couples to know, that of all infertility cases, at least 50 per cent of the issue is due to male factors and poor quality sperm.

Lycopene increases sperm quality

This is the first ever double-blind randomised controlled trial to assess the impact of giving men a bio-enhanced form of lycopene (called LactoLycopene) to see if it helped with sperm quality. The team from the university of Sheffield discovered that the lycopene supplementation made no significant difference to sperm count and concentrations. However the rapid progressive motile sperm and the sperm with normal morphology increase by around 40% in response to the lactolycopene intervention. Rapid progressive sperm and morphology are the two most important parameters for sperm quality and for increasing chances of fertilisation and pregnancy.

During the 12-week trial half the recipients took LactoLycopene supplements and the other half took identical placebo (dummy pills) every day for 12 weeks. Neither the researchers nor the volunteers knew who was receiving the LactoLycopene treatment and who was receiving the placebo. Sperm and blood samples were collected at the beginning and end of the trial. The researchers were surprised by the improvement in the sperm quality shown by the results. The improvement in morphology and rapid progressive sperm was dramatic after lycopene supplementation.

What are Lycopenes?

Lycopene can be found in some fruits and vegetables, but the main source in the diet is from tomatoes. However, the bioavailability of lycopene from fresh tomatoes is low, but this is enhanced by a special natural processing technique of heating and infusing tomatoes with oil. As such, this study used lactolycopene, the main ingredient of which lycopene is embedded in a special protein mix for enhanced intestinal absorption.

This was the first properly designed and controlled study of the effect of LactoLycopene on semen quality, and it has spurred researchers to want to do more research into lycopene and well as other antioxidants and amino acids that may help with sperm quality. The research also shows the role these antioxidants play in helping inhibit the damaging effects of oxidation and oxidative stress.

Oxidation and Oxidative Stress Damage Sperm

Oxidation and oxidative stress is a known cause of damage to sperm and the sperm DNA. Lycopene is a powerful antioxidant that is potentially inhibiting oxidation and the damage of oxidative stress causes to sperm quality. Researchers believe this antioxidant is the key to improvements in sperm quality seen in this trial and could be an answer to the cause of many male fertility problems. More research is needed and the research team is hoping to embark on a new study as soon as possible.

Final Word

As part of my fertility program all males are educated on the importance of preconception care and about optimum sperm health. All men on my fertility program are given antioxidants and supplements that have been shown to assist with sperm quality and maintain optimum sperm health. Men are 50% of the equation of making a baby and why all men need to be included in any preconception care and any program to assist couples in having a baby.

Regards

Andrew Orr

-No Stone Left Unturned

-Master of Reproductive Medicine

-The International Fertility Experts

 

Journal Reference:

  1. Elizabeth A. Williams, Madeleine Parker, Aisling Robinson, Sophie Pitt, Allan A. Pacey. A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy malesEuropean Journal of Nutrition, 2019; DOI: 1007/s00394-019-02091-5
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Why you cannot manage your disease by yourself!

In this video post, I am going to talk about why you cannot manage your disease by yourself.

Many of us like to think we can treat ourselves, or manage our own disease, or even control every aspect of our lives, but the reality is.. .we can’t.

All to often I see many people trying to manage their own disease state and some of these people are actually healthcare practitioners themselves. The problem is that nobody can manage their own health issue and it is not safe to do so, because of being too close to it. Then the judgement becomes clouded and then this can lead to a vicious cycle of mismanagement and frustration too.

Have a listen to my latest video blog about this issue. I am also talking about this from personal experience and from someone who knows what many people go through too. Today was one of my bad day, so I have an open and honest talk about why you cannot manage your own disease yourself.

No matter who you are, everyone needs help from someone who specialises in the disease that they have. There is help out there. You just have to find the right people to help you.

If you do need help with managing a chronic disease, you can also give my friendly staff a call and find out how I may be able to assist you.

 

Take care

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate