Tag Archives: Probiotics

microbiome for weight loss

Let’s Talk About Prebiotics & Probiotics & Their Role in Health & Weight Loss

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In my latest post I thought it was important to talk about Prebiotics and Probiotics and their role in health and weight loss. With the upcoming new years resolutions of weight loss and overall health, I thought it was important to discuss this topic. Strain specific probiotics and prebiotics not only assist with weight loss, but they assist with the mind, the gut, reducing inflammation and overall health. Of course, to lose weight, you also need to cut refined carbohydrates, increase good protein sources and also exercise. Just to be clear on that. But, we also need to acknowledge the role of beneficial bacteria in this process as well.

I’ve talked about the importance of a proper microbiome restore before (click here), but I thought I would explain it in person, rather than just in word form, so that people understand this topic better. Before you start any weight loss challenge, you need to listen to my latest video post first.

If you do need assistance in losing weight, maintaining health and doing a proper microbiome restore, please give my staff a call and find out how I may be able to assist you.

Medications affecting the microbiome

Many Medications Significantly Affects The Microbiome

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New research is emerging to show that many medications significantly affect the microbiome and lead to long term health implications through disruption of healthy gut bacteria.

As mention already in my previous post about the importance of proper restoring the microbiome for optimum health, many medications and hormones actually have a toxic affect on the microbiome and can cause dysbiosis. It is crucial to for all of us to understand the consequences of medication use in the gut microbiome. I’ll talk about this in my next post.

A new study has found that many common drugs — including those that treat diabetes, digestive problems, bacterial infections, and even depression — could actually predispose people to certain types of infection by affecting the balance of their gut microbiome.

New findings

A new study from the University Medical Centre Groningen and the Maastricht University Medical Centre, both in the Netherlands, has found evidence to suggest that many common drugs — from antibiotics to antidepressants — have a significant impact on the gut microbiome. They can even disrupt the delicate balance of bacterial populations.

The researchers compared the results of people who took prescription drugs with those of people who did not. They also looked at the effects of individual medications versus combinations of drugs.

They found that 18 common drug categories have a significant impact on the bacterial composition of the gut microbiome, which could lead to serious health issues. These health issues included intestinal infections, obesity, gastrointestinal conditions and various conditions linked to gut health.

Many Medications Disrupt The Microbiome

While pain medications, steroids, antidepressant and hormones (contraceptives and hormone replacement) were shown to significantly impact the bacterial balance in the microbiome, four drug categories appeared to have the strongest impact. These were:

  • Proton pump inhibitors (PPIs), which reduce the production of stomach acid
  • Metformin, which helps people manage the symptoms of type 2 diabetes
  • Antibiotics, which fight bacterial infections
  • Laxatives, which help treat constipation

The analyses revealed that people who took PPIs had more upper gastrointestinal tract dysbiotic bacteria, and that their bodies produced more fatty acid. Meanwhile, those who took metformin had higher levels of Escherichia coli, a bacteria that can cause diarrhoea and urinary tract infections. One of the reasons many stop Metformin is because of significant gastrointestinal symptoms and pain. Long term it can also damage the liver.

Antibiotics Significantly Impact The Microbiome

We have always know that antiobiotics have an major impact on the gut and microbiome, but many people are unaware that all medications have the potential to disrupt the microbiome and cause significant harm to our health long term.

When it comes to antibiotics, alarmingly Australians are amongst the highest users of antibiotics in the world with 46% of the population taking one course of antibiotics annually.

A single course of antibiotics can disrupt the gut microbiota quantity and composition for up to four years. The loss of microbial balance leads to a breakdown of endothelial barrier protection, increased intestinal permeability, and subsequent immune dysregulation.

Proper Microbiome restore needs to be done properly

As mentioned in my previous post, the good news is although a dysfunctional microbiome can come about rapidly, you can begin to restore a healthy microbiome just as quickly through strategic microbiome restore.

As I have said before, when it comes to proper microbiome restore,  it isn’t just as easy as taking any old probiotic, or a combination of probiotics. Microbiome restore requires and individualised and strain specific approach and it needs to be done in stages with antimicrobials, gut repair and prebiotics as well. Dysbiotic microbes can be hard to treat effectively because they have evolved and adapted to life inside human beings. Consequently, elimination of these organisms requires a similarly evolved and adapted approach. This is all part of the microbiome restore protocol I use with my patients.

If you would like to find out how to restore your microbiome properly, please give my friendly staff a call and find out how I may be able to assist you.

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate

 

Microbiome

The Importance Of Properly Restoring The Microbiome For Optimum Health

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One of the things I teach my patients is the importance of properly restoring the microbiome for optimum health and also reducing inflammation in the body.

Many people’s daily bloating, fluid retention, gastrointestinal symptoms, health issues, chronic disease states are being exacerbated by an unhealthy balance in this unique ecosystem we call the microbiome.

The problem is that many people do not really understand the importance of the microbiome, and even many healthcare professionals do not fully understand how to help with proper microbiome repair and restore.

Many people are also led to believe that by just taking probiotics, that this is enough to restore the healthy bacteria in the gut/microbiome.

I wish it was that easy, but it isn’t and this is why many people continue to have gastrointestinal issues, inflammation and chronic health issues, despite thinking that are doing the right thing for their gut health.

What is the Microbiome?

The human gastrointestinal tract (GIT) is host to an extraordinary amount of microorganisms composed of bacteria, viruses and microbes, collectively known as the microbiome. The microbiome is the name given to all of the genes inside these microbial cells.

Every human being has anywhere between 10 trillion and 100 trillion microbial cells all working together in a symbiotic relationship. This benefits both the microbes and their hosts, as long as the body is in a healthy state.

Recent scientific advances in genetics mean that humans know a lot more about the microbes in the body. There has been lot of time and money put into researching the interactions within the human body’s ecosystem and their relevance to health and disease.

The two terms ‘microbiota’ and ‘microbiome’ are often used to mean the same thing and are used interchangeably. I will explain the differences between them and how both are being used and researched in modern medicine.

You exist in a symbiotic relationship with your bacterial ecosystem, and there is a two-way relationship that makes your health inseparable from that of your microbiome and vice versa.

The benefits of a healthy microbiome/microbiota

The benefits of a healthy microbiome/microbiota, extend beyond the gut and digestive system and has a significant systemic impact on some the following:

  • Nutrient metabolism
  • Body composition (weight)
  • Cardiovascular health,
  • Chronic disease states
  • Inflammation in the body
  • Pain pathways
  • Immunity
  • Mental Health
  • Neuroendocrine function
  • Gene Expression

What is the Microbiota

The gut microbiota used to be called the microflora of the gut. The importance of the microbiota has been known for a long time, but now medical science is discovering just how important it is, and it is now becoming a cornerstone of preventive medicine.

The gut microbiota contains over 3 million genes, making it 150 times more genetically varied than the human body. The gut microbiota of each individual is very unique and it has a major contribution to how a person fights disease, digests food, and even his or her mood and psychological processes.

This symbiotic relationship greatly benefits humans. The presence of this normal flora includes microorganisms that are so present in the environment that they can be found in practically all animals from the same habitat.

However, while there are good bacteria found within these native microbes, some of these microbes also include harmful bacteria that can overcome the body’s defences that separate them from vital systems and organs. There are beneficial bacteria in the gut, and there are harmful bacteria that can cross into wider systems and can cause local infections of the GI tract. These infections can then cause infection and inflammation and can also worsen disease states in the body.

What is dybiosis?

The microbiome plays an important role in resisting intestinal overgrowth of externally introduced populations that would otherwise cause disease. In our microbiome, the “good” bacteria compete with the “bad,” with some even releasing anti-inflammatory compounds.

Bacterial dysbiosis produces an endotoxin called lipopolysaccharide (LPS). It is one of the most inflammatory substances known. LPS is also major contributor to the inflammation, which then drives many chronic health conditions and disease states.

These bad bacteria are called dysbiotic bacteria and cause a process called ‘dysbiosis’.

Broadly speaking, dysbiosis indicates the existence of either the wrong microbiota (e.g. overgrowth of bacteria, fungi and/or parasites) and/or the wrong numbers of the right microbiota (imbalances in composition), or either, in the wrong place.

Dysbiosis causes increased gut and intestinal permeability, which can lead to what we call leaky gut, or leaky gut syndrome. Dysbiosis can also consequent lead to up-regulation of inflammatory pathways and lead to increased inflammation in the body.

Dybiosis is implicated in many chronic diseases

Dysbiosis is very common it the western culture and bacterial dysbiosis is now being linked to causing, or exacerbating many health conditions and disease states. Research has found links between bacterial populations, whether normal or disturbed, and the following diseases:

  • Endometriosis
  • Adenomyosis
  • PCOS
  • Asthma
  • Autism
  • Auto-immune conditions
  • Cancer
  • Celiac disease
  • Colitis
  • Inflammatory Bowel Disease
  • IBS
  • Crohn’s Disease
  • Diabetes
  • Eczema
  • Heart disease
  • Malnutrition
  • Multiple sclerosis
  • Arthritis
  • Obesity
  • Metabolic Syndrome

What Causes Dysbiosis?

There are many things that lead to bacterial overgrowth, which then leads to dysbiosis. This is why many people suffer bloating, reflux, nausea, constipation, inflammatory bowel symptoms, and many other gastrointestinal symptoms daily.

Day-to-day risk factors include a western-based diet, overly hygienic living (being too sterile), alcohol, certain medications, hormones and the use of antibiotics.

Mood disorders, stress and being overly busy are also a big factors with creating dysbiosis and something that many overlook, or do not even realise. Yes, stress is a big factor in many gastrointestinal symptoms people experience daily.

With all these factors it means that almost everyone will have some degree of dysbiosis at some point in their life.

Many constantly have dysbiosis and why they often have long-standing digestive symptoms such persistent pain and bloating, constipation, alternating diarrhoea or other digestive imbalances. We also commonly see this with endometriosis and the dreaded “endo belly”

Medications Cause Dysbiosis and Significantly Affect The Microbiome

As mention already, many medications and hormones actually have a toxic affect on the microbiome and can cause dysbiosis. It is crucial to for all of us to understand the consequences of medication use in the gut microbiome. I’ll talk about this in my next post.

The good news, however, is although medications can cause a dysfunctional microbiome quite rapidly, you can begin to restore a healthy microbiome just as quickly through strategic microbiome restore.

Proper Microbiome Restore Protocols

When it comes to proper microbiome restore,  it isn’t just as easy as taking any old probiotic, or a combination of probiotics. Microbiome restore requires and individualised and strain specific approach and it needs to be done in stages with antimicrobials, gut repair and prebiotics as well. Dysbiotic microbes can be hard to treat effectively because they have evolved and adapted to life inside human beings. Consequently, elimination of these organisms requires a similarly evolved and adapted approach. This is all part of the microbiome restore protocol I use with my patients.

A New Understanding

When it comes to the perfect microbiome, researchers have discovered there is no ‘one size fits all’ across various populations. It is important to recognise that not all strains are created equal when it comes to their ability to rebuild a healthy microbiome.

What is now known is that there are only certain types of good probiotic bacteria that have benefit for our gut and microbiome, and that some strains of probiotic bacteria have no benefit. These new finding mean that we need to adopt a strain specific approach when repairing and restoring the microbiome.

From recent investigations and research, the best results are gained by introducing strain specific influential probiotic that have beneficial functions. These specifically influential strains are able to restore each patient’s unique microbiome by promoting the growth of key commensal (symbiotic) groups, but also by improving overall GIT function.

The Importance of Prebiotics

In addition to prescribing a specific probiotic formulation, prebiotic therapy is needed to help support and encourage the establishment of healthy microbiota by significantly increasing the numbers of beneficial bacteria. Without prebiotics, the probiotic bacteria do not grow and this is why they are essential for microbiome restore. Prebiotics are not talked about enough and many people do not realise their importance and often wonder why their probiotics are not working effectively enough.

Prebiotics are also needed to promote the growth of healthy microbiota, begin refurbishment of gut mucosa and improve gastrointestinal immunity. Prebiotics also help with inflammation and also support the integrity of the intestinal barrier, provide healthy immune responses and promote intestinal microbiome balance.

Microbiome Restore Protocols

With emerging research now highlighting the significance of developing and maintaining a healthy microbiome, it is important that everyone knows the importance of appropriate probiotic and prebiotic combinations. By supporting the restoration and repair of our micriobiome, we can all optimise our health, improve treatment outcomes and also help with reducing the risk of many chronic disease states.

If you would like to find out how to restore your microbiome properly, please give my friendly staff a call and find out how I may be able to assist you. Online and in person consultations are available. Some conditions apply.

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate

References
  1. Walker A, et al. Phylogeny, culturing, and metagenomics of the human gut microbiota. Trends Microbiol. 2014;22:267–74.
  2. Collado MC, et al. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007;45(4):454-60.
  3. Leahy SC, et al. Getting better with bifidobacteria. J Appl Microbiol. 2005;98(6):1303-15.
  4. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16(18):2202-22.
  5. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  6. Jahn HU, et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion. 1996;57(2):95-104.
  7. Dahan S, et al. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli induced signaling pathways in T84 cells. Infect Immun. 2003;71:766-773.
  8. Hsieh H. Versalovic J. The human microbiome and probiotics: Implications for pediatrics. Curr Probl Pediatr Adolesc Health Care. 2008;38(10):309–327.
  9. Lam EK, et al. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci. 2007;80(23):2128-36.
  10. Seth A, et al. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008;294(4):G1060-9.
  11. Gibson GR. Roberford M. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401-1412.
  12. Fastinger ND, et al. A novel resistant maltodextrin alters gastrointestinal tolerance factors, fecal characteristics, and fecal microbiota in healthy adult humans. J Am Coll Nutr. 2008;27(2):356-66.
  13. Raninen K, et al. Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose. Nutr Rev. 2011;69(1):9-21.
  14. Robison LE. Reeves S. EpiCor® and its immune effects on gut health. Embria Health Sciences, LLC. [Online]. No date. Available from: http://www.embriahealth.com/upload/pdf/EpiCor%20Science%20%20EpiCor%20and%20its%20Immune%20Effects%20on%20Gut%20Health_FINAL.pdf [Cited 16/02/13].
  15. Jensen GS, et al. Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food. 2011 Sep;14(9):1002-10.
  1. Bartoli, C., Frachon, L., Barret, M., Huard-Chauveau, C., Mayjonade, B., Zanchetta, C., … & Roux, F. (2018, May 30). In situ relationships between microbiota and potential pathobiota in Arabidopsis thaliana. The ISME Journal. Retrieved from https://www.nature.com/articles/s41396-018-0152-7#article-info
  2. Berg, R. D. (1996). The indigenous gastrointestinal microflora. Trends in Microbiology, 4(11), 430-435. Retrieved from https://www.sciencedirect.com/science/article/pii/0966842X96100573
  3. Carpenter, S. (2012, September). That gut feeling. Monitor on Psychology, 43(8), 50. Retrieved from http://www.apa.org/monitor/2012/09/gut-feeling.aspx
  4. Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017, September 15). Gut microbiota’s effect on mental health: The gut-brain axis. Clinics and Practice, 7(4), 987. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/
  5. NIH Human Microbiome Project. (n.d.). Retrieved from https://hmpdacc.org/
  6. Shepherd, E. S., DeLoache, W. C., Pruss, K. M., Whitaker, W. R., & Sonnenburg, J. L. (2018, May 9). An exclusive metabolic niche enables strain engraftment in the gut microbiota [abstract]. Nature, 557, 434-438. Retrieved from https://www.nature.com/articles/s41586-018-0092-4
  7. The Human Microbiome Project Consortium. (2012, 14 June). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. Retrieved from https://www.nature.com/articles/nature11234
  8. Ursell, L. K., Metcalf, L., K., Wegener Parfry, L., Knight, R. (2012, August). Defining the human microbiome. Nutrition Reviews, 70(Suppl 1), S38-S44. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426293/
IBS

Managing Irritable Bowel Syndrome & Inflammatory Bowel Disease

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Irritable Bowel Syndrome, or IBS, is a problem that affects a staggering 3million people, or more, in Australia and about 20% of people world-wide. It is a condition that has baffled doctors for years. There is no single cause, no specific treatment and, as yet, no cure.

But first let’s look at some general information on IBS.

IBS is more common in women than in men and occurs more often in younger people. IBS is usually ongoing, and there are some times when symptoms are worse than other times. Having IBS does not mean you are more likely to develop colon cancer later in life.

Symptoms of IBS

Some people with IBS mainly have constipation, others have diarrhoea. Many people with IBS alternate between periods of constipation and diarrhoea.

Symptoms include:

  • Cramps and bloating in your lower abdomen, which usually get better after having a bowel motion or passing wind
  • Pain that can be a sharp or dull feeling
  • Constipation: feeling that you have not managed to empty your bowels completely, having bowel motions less often, straining to pass a motion or passing small, hard stools
  • Diarrhoea: having bowel motions too often and passing loose stools
  • Flatulence, or wind, and/or rumbling noises from your abdomen
  • Needing to rush to the toilet
  • Headaches
  • Mucus in your stools

Some of these symptoms can also be from other inflammatory bowel diseases such as Crohns disease and Ulcerative Colitis, which sometimes get categories as IBS.

But some of the symptoms above can also be part of having endometriosis and many women who are diagnosis with IBS, in fact have endometriosis. They then have all the testing for IBS, Crohn’s, ulcerative colitis etc (colonoscopy etc) as these don’t find anything and then these women are often told by doctors they are at a loss to what is happening. This is why endometriosis often takes up to 12 years for definitive diagnosis, which is terrible.

IBS triggers

The cause of IBS is not known, but certain things can trigger its symptoms, including:

  • Stress
  • Depressed mood
  • Food poisoning
  • Tummy bug
  • Virus
  • Certain foods and drinks
  • Some medication
  • Some people find avoiding alcohol, caffeine and nicotine can reduce their IBS symptoms

As said before some women suffer more acutely from symptoms of IBS just before, or during, their menstrual cycle. IBS symptoms can also mean that they have a condition called Endometriosis. Many times these conditions can be overlooked and they can be present at the same time, along with bladder issues as well.

Lactose and wheat intolerance and wheat may be a cause and needs to be assessed before permanent changes to diet are made. Wheat grains are inflammatory to the bowel anyway and they should be removed if anyone does have inflammatory bowel issues.

Treatments

There are a few medical treatments available but results can be varying. Many people with severe IBS end up on steroids to settle inflammation in the bowel. There are also other medications to slow bowel motility and reduce inflammation as well.

Dietary and lifestyle changes may assist with the management of endometriosis.

There are also other complementary therapies and treatments that may be assistance and combined with medical interventions, or other interventions..

Studies have shown that strain specific probiotic bacteria may assist with inflammatory bowel conditions such as ulcerative colitis and IBS. But, this needs consultation with a qualified healthcare professional to treat disease properly. Self-prescribing is not an option for this disease that affects over 3 million people here in Australia alone.

With any disease state such as IBS, there needs to be an individualised approach, not a one treatment fix all approach, because everyone is uniquely difference in their symptoms they experience and what their triggers are. There also needs to be a multimodality approach because many times IBS overlaps with conditions such as endometriosis for women, and other inflammatory conditions in men.

If you have IBS or inflammatory bowel disease and need help and assistance in managing your symptoms better, please give my friendly staff a call and they will explain how I may be able to assist you.

Regards

Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Advocate

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Food additives and emulsifiers may increase inflammation and anxiety

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A wide range of foods contain ingredients that we call emulsifiers. A new study has shown that these compounds can produce both physiological and behavioural changes.

Bread and many other common foods we eat daily contain emulsifiers and other additives.

Food additives have always generated a great deal of attention as they can lead to exacerbating many health conditions, or even be the cause of some health issues as well. Recently, emulsifiers have been drawing fire and rightfully so.

Manufacturers have been using these chemicals to alter food’s texture and extend its shelf life for years and they are not good for our health. These emulsifiers are found in many foods such as bread, chocolate, margarine, processed meats, and more.

Earlier studies have shown that emulsifiers can alter the microbiome of mice, causing low-grade inflammation and increasing the risk of obesity and metabolic disorders. But now a study in humans concluded that gut bacteria “can be directly impacted by these commonly used food additives, and these additives also subsequently drives intestinal inflammation.”

Recently, researchers from Georgia State University in Atlanta set out to see if these emulsifiers also influenced mental wellbeing. The focussed on two commonly used emulsifiers — carboxymethylcellulose (CMC) and polysorbate-80 (P80).

The Microbiome and Psychological health

In many recent studies scientists have already described a clear pathway between the gut and the brain. These studies have shown that our gut health and the health of our gut bacteria can have a substantial influence on our mental well-being. Most of the studies concluded that lack of good bacteria in the gut and overuse of antibiotics could significantly alter the microbiome, anxiety levels, and social behaviour over the long-term.

This most recent study investigated whether P80 and CMC might alter our mental state. The team added CMC and P80 to the drinking water of recipients for 12 weeks. They then measured the changes in the microbiome, behaviour and other physiological changes as well. The results showed that these emulsifiers caused general systemic inflammation, which extended to the brain and to behavioural changes. The researchers published their findings in the journal Scientific Reports.

The impact of emulsifiers

The scientists showed that the emulsifiers did impact good gut bacteria, but in different ways for male and females. They also showed that the changes in behaviour were different between the sexes. Males tended to have an increase in anxiety, where the females tended to have a reduction in social behaviour.

While it is not known how these emulsifiers affect behaviour, it is speculated that the inflammation they produce affects signalling pathways in body tissue and parts of the brain. The gut also contains branches of the vagus nerve, which has a direct link to the brain. The researchers said that more research is needed into this very important area of medicine.

In recent years there have been increase levels of anxiety and mood disorders in our western society. While there are many other factors to the increase of anxiety and mood disorders, such as stress and lifestyle changes, the researchers have questioned if these additives may also be playing a part in this as well.

For now, the researchers recommend that we should really look at how these food additives impact our microbiome and gut bacteria and increase systemic inflammation in the body. It is great to see that science has now showing, beyond a shadow of a doubt, that the microbiome plays a significant role in our overall health. Not just our physical health, but our mental and emotional health as well.

This is why I always recommend health diet and lifestyle changes for every condition I help with. This is also why I promote the use of healthy beneficial bacteria (probiotics) daily in our diet as well. Good health always starts with good diet. Good health always starts with a healthy gut/microbiome as well.

Take care

Regards

Dr Andrew Orr

-Women’s and Men’s Health Expert

-No Stone Left Unturned

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