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Mediterranean Style Diet May Help to Improve Pregnancy Rates for Couples Undergoing IVF and Assisted Reproduction.

New research published in Human Reproduction, has found that those who follow a “Mediterranean” style diet at least six months before assisted reproductive treatment have a significantly better chance of becoming pregnant and giving birth to a live baby than women who did not.

As part of my Fertility Program, one of the first things I talk to couples about is the importance of a healthy diet that has adequate protein, lots of vegetables, seeds and nuts, healthy oils, adequate water intake, electrolytes and cutting out all the refined carbohydrates that cause inflammation. The hard thing is that I hardly see a couple following those health food principles, with many not even really knowing what a health diet is. The diet that I promote is a Primal based diet.

Previous studies have shown that when refined carbohydrates are cut out and replaced with proteins, essential fats and good carbohydrates, such as fruit and vegetables, that the clinical pregnancy rates shot up by 80%. (Fertility & Sterility 2012 Volume 98 issues 3 Page S47)

In this new study, researchers focussed in dietary patterns rather than individual nutrients, food, or food groups. They found that those who ate lean protein, more fresh vegetables, fruit, fish and olive oil, had a 70% greater likelihood of achieving a successful pregnancy and birth compared to women who didn’t follow this style of diet.

The research outcomes found that out of the 244 women in the study, 229 women (93.9%) had at least one embryo transferred to their wombs; 138 (56%) had a successful implantation; 104 (42.6%) achieved a clinical pregnancy (one that can be confirmed by ultrasound); and 99 (40.5%) gave birth to a live baby.

The most important message to come from the study is that women attempting to have a baby should be encouraged to eat a healthy diet, such as a Mediterranean style diet, because it may help increase the chances of successful pregnancy and successful live birth.

The researchers did note that when it comes to conceiving a baby, diet and lifestyle are just as important for men as for women. Previous studies from the same research group showed that male partners that adhered to the same sort had better semen quality.

A healthy diet is important for all couples prior to trying to conceive and should be a part of any preconception planning by all healthcare practitioners assisting couples with fertility. While this study focussed on improving assisted reproduction pregnancy rates, this style of diet should be adopted by any couple wanting to have a baby and should be implemented at least 6 months prior to conceiving. This is why it is essential for all couples to receive counselling and guidance on the importance of a healthy diet and having a healthy lifestyle as well. This is a foundation of my fertility program that has helped over 12,500 babies into the world and continues to help many more couples reach their goal of becoming parents.

Regards

Dr Andrew Orr

Reproductive Medicine and Women’s Health Medicine Specialist

-No Stone Left Unturned

-The Brisbane Baby Maker

Dr Andrew Orr Logo Retina 20 07 2016

Stressed Uterine Cells & Inflammation Cause Miscarriage, Not Natural Killer Cells

It is stressed uterine cells and inflammation causing miscarriage and causing the embryo not to implant, not Uterine Natural Killer cells.

For the first time the functions of natural killer cells in the womb have been identified by Researchers at the University of Warwick and University Hospitals Coventry

Although it has long been known that the lining of the womb harbours dynamic uterine natural killer cells, no functions have so far been given to these cells outside of pregnancy.

The researchers have discovered that the uterine natural killer cells remodel and refresh the lining of the womb at the time of embryo implantation. This is the first time a role for uterine natural killer cells in the lining of the womb has been identified outside of pregnancy. The research was published on December 14, 2017.

In addition they discovered that this process isn’t always balanced in each cycle. The natural killer cells perform the role of targeting and clearing inflammatory stressed cells, thereby making space for the implanting embryo. However sometimes not enough of these cells are cleared away and sometimes too many are targeted and removed. Excessive inflammation or insufficient clearance by uterine natural killer cells makes miscarriage more likely.

For many years I have been trying to tell people that they need to stop trying to get rid of the natural killer cells, or reduce their numbers. I have long known that natural killer cells are meant to be in the body and their job is to protect us from infections, bacteria, cancers, tumours and inflammation. If killer cells are in high numbers, it means that there is something wrong and that is what needs to be treated, not the killer cells. But unfortunately, many clinics play on couples emotions and the use of the word “Killer”. So then we get this war on killer cells and people wanting to kill the killer cells because they think it is killing their babies. No matter how hard I have tried to explain it, people just don’t listen and now it is finally great to have the research to back up what I knew all along, plus additional knowledge of how Killer cells actually help with implantation and reducing miscarriage.

The researchers have explained what happens if the natural killer cells cannot do their job properly, or there is inflammation that they haven’t been able to target. They said that a good analogy is Swiss cheese: without holes, the embryo has nowhere to go which will cause implantation failure; but if the holes are too large, the tissue will physically collapse and lead to miscarriage. This imbalance, which may be short-lived or last for multiple cycles, explains the high rate of early pregnancy failure. It really can be a numbers game on how long that cycle could last and why it is important to make sure there are enough natural killer cells there to do their job properly. Without the natural killer cells, there is more chance of inflammation and stressed uterine cells being left behind, which will then lead to higher pregnancy loss and reduced implantation.

The researchers conducted an analysis of 2,111 endometrial biopsies, which is more than had ever been conducted previously. The research team examined the acutely stressed cells in the lining of the womb which generate tissue inflammation. They found that the natural killer cells which are in the womb perform the important function of selectively targeting and eliminating acutely stressed cells.

When there are high acutely stressed cells in the lining of the uterus, the lining of the uterus fails to sense the chemical signals from the fertilised egg and it then silences many of the genes involved in allowing the embryo to implant and embed into the uterus.

One of the chemicals needed for this process to take place is Trysin, which is a common enzyme the embryos gives off. If trysin isn’t detected the embryo is not accepted and left to disintegrate and then the cycle is reset once again. The lack of Trysin signal appears to indicate to the endometrium that the quality of the embryo is not very high and initiates a reduction of receptivity to implantation. These findings could help to improve the success rates of IVF, because one of the biggest problems with IVF is getting the embryo to implant

The research team also found that high numbers of Natural Killer cells in the endometrium are not only a sign of high inflammation and acutely stressed uterine cells, but also indicate a insufficient production of steroids, which in turn leads to reduced formation of fats and vitamins that are essential for pregnancy nutrition.

Again, this is exactly what I have been trying to say for years and why when I treat women who are having implantation issues and recurrent miscarriage I look at treating the cause of the issue, rather than masking it.

To treat miscarriage and help with embryo implantation you need to do the following

  1. Reduce inflammation in the uterine environment and pelvic cavity
  2. Make sure the pelvis, tubes and uterus have been surgically evaluated properly prior to conception, or assisted reproduction (IVF, IUI, ICSI etc)
  3. Increase blood flow and nutrients into the uterine lining
  4. Ensure adequate essential fats and nutrients are given prior to conception
  5. Reduce stress levels
  6. Increase protein and reduce inflammatory refined carbohydrates
  7. Make sure the couple in are optimum health (healthy sperm + healthy eggs=health baby)
  8. Make sure the man is being treated at the same time the woman is (up to 85% of miscarriage issues are related to chromosomal and DNA factors related to poor quality sperm, which cannot be measured by a normal semen analysis)

We need to stop blaming high NK cells as being the cause of miscarriage and embryos not implanting. We need to look at the real cause, which is inflammation, stressed uterine cells ( due to stress in the person), lack of nutrients and blood flow in the uterus and lifestyle factors that is also leading to increase miscarriage rates and reduced embryo implantation. This is why I have my own range of fertility formulas to assist the uterine environment and help with implantation.

Let’s not forget that faulty sperm and DNA damage and chromosomal issues with sperm are also a big part of miscarriage too. Miscarriage is not just a woman’s issue. To be honest, statistically it is more likely to be on the male side of the equation and often gets overlooked. But that is a whole other post in itself.

This is why I offer a comprehensive fertility program that looks at every aspect of the couple and every aspect of fertility. It is also why I have helped over 12,500 babies into the world. It is about my motto of “No Stone Left Unturned” and treating the cause of people’s issues, not just guessing and trying to treat the symptoms as you go along.

Hopefully in the future this new information will be used to screen women at risk of reproductive failure and help with new treatment options for women suffering recurrent miscarriages or recurrent IVF failure.

If you are having trouble conceiving and want answers to your fertility issues, then maybe it is time to book into my fertility program and get some real answers, real treatment and get the baby you so desperately deserve.

Regards

Dr Andrew Orr

Reproductive Medicine & Women’s Health Medicine Specialist

-The International Baby Maker

-No Stone Left Unturned

No Bad Carbs + Increased Protein = Increased Fertility & Increased Pregnancy rates

I know I talk about it all the time, but a good diet, and I mean a good diet (not half hearted, I am trying to do it diet), can actually increase your fertility and pregnancy rates

Every day I get people ask me “What can I do to increase my fertility and my chances of pregnancy?”

Well, I always say “How long is a piece of string?”, but while there are many things that people can do to increase their fertility, one being start of my fertility program, the other important one is starting with a good diet. That is one thing “You” are solely responsible for and something “You” can do for yourself. This is for the couple too. Not just the woman.

Healthy couples produce healthy babies. That means health men produce healthy sperm and healthy women produce healthy eggs and the combination creates healthy embryos that go on to become healthy babies. It really is a fact. Even for same sex couples, a partner should be supporting their other half in the journey and at the end of the day a healthy diet is going to help everyone live longer to enjoy their children later on, and hopefully grandchildren too.

Obviously there is a lot more to it, and why in my fertility program I cover “everything” for the couple,  but this is one way to ensure your body is ready to have a baby. This is also part of my PACE (Primal, Ancestral, Clean Eating) diet that I have formulated.

Recent studies have shown that when the bad carbohydrates are removed and the protein increased, that the clinic pregnancy rates shot up by 80%. Yes… a massive 80%

The other thing that is important is that eating this way also improved the embryo quality. Blastocyst development was higher in the high-protein group than in the low-protein group (64% vs 33.8%), as were clinical pregnancy rates (66.6% vs 31.9%) and live birth rates (58.3% vs 11.3%).

Reducing carbohydrates and boosting protein intake can significantly improve a woman’s and couples chance of conception and birth according to the research presented at the American Society of Reproductive Medicine (ASRM) several years ago.

The effect is “at the egg level,” said lead investigator. He presented the findings here at American Congress of Obstetricians and Gynecologists 61st Annual Clinical Meeting.

Carbohydrate-loaded diets create a hostile egg and embryo environment even before conception or implantation, he explained.

“Eggs and embryos are not going to do well in a high-glucose environment.” By lowering carbs and increasing protein, “you’re bathing your egg in good, healthy, nutritious supplements,” he said.

These studies demonstrate how little many in the reproductive medicine and fertility profession know about the effect of micronutrients in our diets on various aspects of reproduction.

These studies demonstrate a field wide open for future research and shows how bad carbohydrates (refined grains, refined sugars etc) have an inflammatory effect that affects fertility and pregnancy outcomes and also detrimental to IVF outcomes.

This is why I always promote a grain free, primal based diet (PACE Diet) to all of my patients, especially my fertility and gynaecology patients. It is an essential part of my overall success rate and why I have been able to help over 12,500 babies into the world and help many with gynaecological issues as well.

Regards

Dr Andrew Orr

Reproductive Medicine & Women’s Health Medicine Specialist

-The International Baby Maker

-No Stone Left Unturned

Vitamin D Increases Fertility & Assisted Reproduction Success Rates.

New research has concluded that there is a relationship between a woman’s vitamin D status and the success rates of assisted reproduction therapy(ART), which includes IUI, IVF and ISCI. While this is research is nothing new, and something I have been promoting for years, finally it is now official. Women trying to conceive should be taking vitamin D supplements, eating vitamin D rich foods, and getting a healthy dose of the sun daily.

Infertility, or what we call subfertility, is becoming an increasing problem and affects millions of people worldwide. More and more people have to turn to assisted reproduction therapy (ART) which now means more and more people are having to use IUI, IVF and ICSI.

The problem is that even with assisted reproduction therapy (ART), at best the success rates are only around 25- 30% on average, and that depends on the clinics individual success rates. Some clinics are also inflating and bodgying success rates to bring in unsuspecting customers.

While there has been much advancements in assisted reproduction (ART) such as IVF and improvements in success rates, the success rates have also started to stagnate. This is why couples need to look at all options to help increase those success rates and this is why I have set up a fertility program that can boost those success rates by as much as 96.1% *. This is why what I do has helped over 12,500 babies into the world and why couples need to look at a multimodality approach to increasing their chances of conception.  I often explain to couples that it is like preparing for a marathon; because that is what doing ART can be like. You need to prepare the body (both the man and woman), get the right diet, get the right nutrients, prepare mentally, prepare physically and basically get the bodies into the best shape possible to give the best success. Nobody should ever run a marathon without adequate preparation and the same goes for assisted reproduction.

Vitamin D and reproduction

Researchers across the board know that there is room for improvement in ART success rates. A range of potential factors are being explored, and some scientists have turned their attention to the potential role of vitamin D. While vitamin D is something that needs to be explored, and something that I give to my patients, it needs to be combined with other things mentioned above. It isn’t just as simple as taking Vitamin D and all your fertility problems are gone. But, it is one of the things that can help increase your overall success rates and should be used.

Most of our vitamin D supply is generated in our skin after exposure to sunlight. We do get some from our diets as well. This means that individuals who live in colder or darker environments are more susceptible to lower vitamin D levels, or those who regularly wear clothes covering the majority of their skin, and those who rarely go outside. The problem these days, many of us have jobs that require us to be inside most of the time and therefore were aren’t getting enough sunlight. The current figures actually show that up to 97% of Australians, and most probably other countries like the US are the same, are actually vitamin D deficient. The other issue is that even though some of us do get out in the sun, it actually needs to be at a certain time of the day, for optimal absorption. The optimal times are 10am and 2pm in the afternoon. The thing is, most of us aren’t getting out in the sun at these times.

A link between vitamin D and fertility has been theorized for many years and based on a number of observations and studies.  This is one of the reasons I have been promoting the use of Vitamin D for more than 20 years now, for those who are on my fertility program. For instance, vitamin D receptors and enzymes have been found in the endometrium. This is why Vitamin D is also good for women with gynaecological issues such as endometriosis, or adenomyosis. It is good for any gynaecological issue really. Vitamin D deficiency has been shown to increase the risk of pre-eclampsia, pregnancy-induced hypertension, gestational diabetes, and lower birth weight. Vitamin D is also essential for a health immune system and reducing inflammation in the body too.  It also helps with bone health.

We have also seen that in animal studies, vitamin D deficiency causes poorer fertility and reduced function of the reproductive organs. Many of our breakthroughs in medical science, actually come from animal studies first, especially when it comes to ART and IVF. Many cows and other animals are now impregnated using ART and advancements in this area have helped with human studies.

Vitamin D deficiency and lower success rates

Getting back to the feature studies, Vitamin D was shown to help women undergoing IVF, or intracytoplasmic sperm injection (ICSI), frozen embryo transfer, or both.

All the participants’ vitamin D levels were checked by blood test. What people need to know is that many of the reference ranges still used  are actually under review and that if levels of vitamin D in the blood are under 100 Nmols\L, then you need to be supplementing. Anything under 75 Nmols/L is actually deficiency in vitamin D.

This analysis of the current research showed that when women, who underwent ART and had adequate vitamin D levels, were “one third’ more like to have a successful live birth compared to those who were deficient. When compared with women who had insufficient vitamin D concentrations, those with sufficient amounts were “46 percent more likely” to have a clinical pregnancy, and “34 percent more likely” to have a positive pregnancy test result.

Vitamin D is something that I promote and all of my fertility patients are on, as well as other beneficial supplements, diet, emotional support, medicines etc. Before you run off trying to buy vitamin D just remember it is just one thing that can help, and it isn’t a miracle cure, but, it can help. Lastly, before using any supplementations, please consult with a qualified healthcare professional and please don’t self-prescribe, or buy products of the internet. Make sure you buy practitioner dispensed supplements only, which are known to be of the highest quality and not filled with all sorts of things such as heavy metal, low levels of arsenic, toxic fillers etc, which is what some supplements off the internet can have.

 

Regards

Dr Andrew Orr

Reproductive Medicine and Women’s Health Medicine Specialist

-The International Baby Maker

-No Stone Left Unturned

The Truth About Natural Killer Cells & Miscarriage

On a daily basis we get people, who are having failed IVF cycles, calling my clinic looking for some miracle pill, to supposedly eradicate the body of natural killers cell and wipe them off the face of the planet in some war like rage, all because they have been told this will bring an end to their fertility woes.

I wish it was that easy and when my staff go on to explain that treating natural killers cells (uterine killer cells), and especially looking at the cause of natural killer cells (uterine killer cells), is complex, there is no one miracle cure, nor some magic pill, people get annoyed and hang up the phone in a huff ,without listening to the reasons why.

One of the things I always say, when people ask me about regulating natural killer cells for fertility purposes, is “How long is a piece of string?”

This is because this subject is very complex and there are many reasons why natural killer cells may be impacting implantation. So, hence the response is always going to be “How long is a piece of string?”

While Natural killer (NK) cells have an important role in the early responses to viral infections, they have also been linked with failure of pregnancy.

Increasingly, clinics are offering blood tests, at an increased cost to the patient, to measure the number and activity of circulating NK cells. As a result of these investigations, many women are offered treatments such as steroids, intravenous immunoglobulins, and tumour necrosis factor blocking agents. The scientific rationale for these tests and treatments, however, is not always supported by our current knowledge of the function of uterine NK cells.

So, I thought it was about time I set the records straight on the BS information, that seems to being handed around as gospel, by money hungry fertility clinics run by big health conglomerates, and by the rotten Dr Google, about natural killer cells (uterine killer cells) and these supposed miracle pills, that will miraculously fix someone’s fertility issues.

Let’s Look at the Facts about Natural Killer Cells Relating to Miscarriage

  1. There is no miracle pill, or one supposed miracle treatment, or a one pill solution to treat, or get rid of natural killer cells. You do not want to get rid of NK Cells.
  2. Natural Killer Cells are a natural part of the immune system designed to target inflammation, kill of cancer cells, kill off bacteria and protect the body from harmful invasion of foreign organism
  3. There is huge difference between natural killer cells that are circulating in the blood stream, compared to uterine killer cells
  4. Uterine Killer Cells are in large numbers during a pregnancy to protect the embryo
  5. Natural Killer Cells are only in large number and are only being sent out by the immune system because there is some inflammatory process going on in the pelvis, or the rest of the body
  6. You cannot regulate Natural Killer Cells numbers unless you first address the inflammatory process that is causing them to be in high numbers in the first place (Eg- Inflammatory gynaecological conditions such as PID, Endometriosis, PCOS, Adenomyosis, Adhesions, STI’s, CIN, HPV, Herpes etc)
  7. Many people have not had the proper initial fertility investigations and testing needed to actually fall pregnant in the first place and looking at Natural Killer Cells, before all that proper testing etc is done, is actually not assessing the patient properly.
  8. If you do not treat the cause of the Natural Killer Cells being in high numbers, you will not be able to reduce the numbers of Natural Killer Cells that are actually doing the job they are meant to do, which is …. Protect the Body.
  9. Many of the so called treatments for Natural Killer Cells, regarding fertility, have never been approved for such treatment and research on it is still inconclusive.
  10. Some of the treatments being proclaimed as miracle cures (Intralipids etc) are purely money making exercises that are preying on the vulnerability of people who have been told wrong information and have this perception of some killer being inside their body attacking their embryos.
  11. Intralipids have never been proven to treat Natural Killer Cells and are derived from highly inflammatory soy based compounds, which then in turn can cause more inflammation.
  12. The drugs used in the treatment of Natural Killer Cells are steroidal based and carry many side effects and are for more harmful to the body that any natural killer cell will ever be. The steroids are also a category C drug that has been shown to have an effect on the neonate
  13. Steroids, such as Prednisone, do work on regulating NK cells, but they do so by suppressing the immune system, thus compromising a person’s immunity. There are also risk to peoples minerals by using these long term and there are also other side effects to the body.
  14. Natural Killer Cells are there to protect the body, not hurt it.
  15. Natural Killer Cells are only attacking embryos because they are seen as foreign body as well and when they are there trying to kill of the diseases and issues causing inflammation in the body, they just happen to kill of any other foreign organism and inflammatory processes at the same time
  16. Again, to address natural Killer Cells, you need to address the inflammatory process as to why they are in high numbers in the first place
  17. The perception around Natural Killer Cells being this “thing” killing off embryos in the body is misguided and is actually not a true representation of what Natural Killer Cells actually do. It is purely often used to tug on the heartstrings of unsuspecting patients, who are highly emotive and clinics use these emotions to get them to pay for treatments that have never been fully proven to work.
  18. The name “Killer Cell” is too often exploited in the wrong context by many in the fertility world
  19. Blood tests cannot measure the number of Natural Killer Cells in the Uterus, Only a biopsy can do this.
  20. A Natural Killer Cell (uterine killer cells) Biopsy has to be done between the 24th and 28th day of your menstrual cycle to give the best results.
  21. Blood tests can only measure the circulating NK cells in the body and not the uterine killer cell activity, which can be the cause of recurrent miscarriage. So, if you have had a blood test, it is not measuring what is needed. Everyone will have circulating NK cells in their blood stream.
  22. The percentage of CD56+ NK cells in peripheral blood in normal healthy individuals varies from 5% to 29% (2)Despite this, more than 12% NK cells in women with infertility or miscarriage has been arbitrarily defined as abnormally raised and used as an indication for treatment (4)
  23. The percentage of NK cells in blood can be affected by many factors including sex, ethnicity, stress, and age too.

Natural Killer cells (Uterine killer cells and other NK cells) are the main immune cell-type found in the uterus. Their numbers increase through the menstrual cycle to peak at the time of implantation. If an embryo does implant, NK cell numbers increase further to 70% of all cells.

Uterine NK numbers start to decrease at around the 20 week mark of pregnancy and are all but absent at the end of pregnancy.

Natural killer cells acquired their name as a result of the initial test used to identify them in vitro. Unlike T lymphocytes, NK cells are able to spontaneously kill cells in a non-MHC restricted manner.

Regrettably, this is a misleading name in reproduction, and the powerful image of maternal cells attacking the fetus is emotive and easily exploited. None the less, these NK cells can kill off the embryo at early stages of pregnancy, but there is nearly always a reason why. That reason is inflammation in the pelvic cavity and uterus. This needs to be addressed to regulate the number of NK cells, not some notion of killing off the “Killer Cells”.

Types of Inflammation causing high Natural Killer Cells (Uterine Killer Cells)

  • Endometriosis & Adenomyosis
  • PCOS/PCO
  • Fibroids, Myomas
  • Vaginal Infections & Bacteria
  • STI’s
  • Cancer, Trauma, Localised Lesions & Others
  • Stress

Yes, stress can lead to a compromised immune system, which then leads to high TNF (Tumor Necrosing Factor) and increase Natural Killer Cells, which then leads to prolonged increase activated T Cells, and this then causes reduced implantation of embryos.

This is also a reason why any inflammation in the uterus or pelvic cavity needs to be addressed to help fix this issue and one of the reasons why any woman having fertility issues needs to be investigated and treated properly. This needs to involve proper differential diagnosis, proper pathology testing, genetic testing and surgical investigations such as laparoscopy prior to any further fertility treatment. A laparoscopy is the gold standard for addressing and treatment of issues in the uterine and pelvic cavity.

Natural Killer Cells (Uterine Killer Cells) can be a part of recurrent miscarriage, but we need to stop the misinformation and perception of them being some killer organism that isn’t meant to be in the body. They are meant to be in the body and the name is all too often exploited by many to offer unproven treatments and medications by clinics trying to increase profits.

If you want to regulate and treat natural killer cells (relating to recurrent miscarriage) properly, you need to find out what is causing them to be there in the first place. There is no magic pill to get rid of Natural Killer Cells. You cannot rid the body of Natural Killer Cells anyway. They are meant to be there. You can only regulate the amount of killer cells doing their job and you need to find out why they are in higher numbers in the first place. This is usually because there is some sort of inflammation, infection, bacteria, or malignancy going on in the body that has not been investigated properly in the first place. Let’s not forget that stress, yes stress, increases the amount of Natural Killer Cells in the body too.

At my clinic, I have a proper Natural Killer Cell protocol and treatment plan that is individually tailored and looks at the “cause” of high number of Natural Killer Cells and makes sure that proper investigations, testing and treatment are administered to treat the person properly. This can also be done alongside current medical protocols such as the Bondi protocol, or California protocol.

Regards

Dr Andrew Orr

(Reproductive Medicine & Women’s Health Medicine Specialist)

-The International Baby Maker

-No Stone Left Unturned

References

  1. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immuol 2002;2: 656-63.[CrossRef][Web of Science][Medline]
  2. Pijnenborg R, Vercruysse L, Hanssens M, Van Assche A. Incomplete trophoblast invasion: the evidence. In: Critchley H, MacLean A, Poston L, Walker J, eds. Pre-eclampsia. London: RCOG Press, 2003: 15-2615. Parham P. NK cells and trophoblasts: partners in pregnancy. J Exp Med 2004;200: 951-5.[Abstract/Free Full Text]
  3. Hiby SE, Walker JJ, O’Shaughnessy KM, Redman CWG, Carrington M, Trowsdale J, et al. Combinations of maternal and paternal innate immune genes influence the risk of pre-eclampsia. J Exp Med 2004;200: 957-65.[Abstract/Free Full Text]
  4. Aoki K, Kajiura S, Matsumoto Y, Ogasawara M, Okada S, Yagami Y, et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995;345: 1340-2.[CrossRef][Web of Science][Medline]
  5. Ntrivalas EI, Kwak-Kim JY, Gilman-Sacchs A, Chung-Bang H, Ng SC, Beaman KD, et al. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001;16: 855-61.[Abstract/Free Full Text]
  6. Bisset LR, Lung TL, Kaelin M, Ludwig E, Dubs RW. Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland. Eur J Haematol 2004;72: 203-12.[CrossRef][Web of Science][Medline]
  7. Kwak JY, Kwak FM, Gilman-Sachs A, Beaman KD, Cho DD, Beer AE, et al. Immunoglobulin G infusion treatment for women with recurrent spontaneous abortions and elevated CD56+ natural killer cells. Early Preg 2000;4: 154-64.
  8. RCOG Scientific Advisory Committee. Immunological testing and interventions for reproductive failure. London: RCOG, 2003. (Opinion paper 5.)
  9. Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database Syst Rev 2003;(1): CD000112.
  10. Daya S, Gunby J, Clark DA. Intravenous immunoglobulin therapy for recurrent spontaneous abortion: a meta-analysis. Am J Reprod Immunol 1998;39: 69-76.

 

 

Alcohol Decreases Fertility & Makes Gynaecological Conditions Worse

In today’s modern society, alcohol has become the cornerstone for social engagements, business dinners and after work relaxation. It is important to realise however, that alcohol can directly impact the fertility of both males and females. In males it can decrease sperm quality, reduce testicular size, decrease libido and cause impotence, all of which can impair fertility. In females it has a more systemic response, affecting the reproductive hormones, leading to abnormalities in the menstrual cycle and an increased risk of miscarriage.

Many men and women these days are actually consuming copious amounts of alcohol and may think that their drinking habits are normal, when compared to others around them. When people do things on a regular basis, it becomes their normal. But truth be told, many people’s drinking habits, both men and women, are actually in the realms of alcoholism. The impacts of that are far reaching and fertility and gynaecological conditions are definitely impacted by alcohol consumption.

Effect of Alcohol on Conception for Men

Fecundability refers to the probability of conception during a particular menstrual cycle. It is dependent on the reproductive potential of both partners. Alcohol decreases fecundability by its effect on sperm quality and quantity. Men who continue to consume alcohol on a regular basis, can decrease their sperm motility, morphology and their DNA in the sperm. All of which are important factors in achieving fertility. While outwardly a man’s sperm may look OK, many forget that inwardly, the sperm DNA could be highly fragmented and unless this is tested every ejaculation, you will have no idea how bad the sperm actually is. A one off DNA fragmentation analysis does not mean the sperm each time is OK. It only measures the sperm from the ejaculate that was tested and sperm quality can change by as much as 20% each ejaculation.

Testicular size is also affected by alcohol intake; and can also affect sperm production. Alcohol is a depressant of the central nervous system (CNS), and can disrupt the autonomic system of the CNS. These effects are temporary and short lived. Abnormal sperm production is also temporary and also can resume after abstaining from alcohol.

One study, this one looking at couples going through IVF treatment, found that for every additional drink a man consumed per day, the risk of conception not leading to a live birth increased by 2 to 8 times. This was especially true if the drinking occurred within a month of the IVF treatment.

Effect of Alcohol on Conception for Women

In women, alcohol affects fecundability, by disrupting the delicate balance of the menstrual cycle. Clinical research data published in the “British Medical Journal” suggests that women, who drank socially, 1-5 drinks per week, were at a greater risk of decreased fecundability when compared to women who remained abstinent. These findings underscore the importance of remaining abstinent while attempting to conceive.

Alcohol disrupts the hormonal imbalance of the female reproductive system, leading to menstrual irregularities, and even Anovulatory cycles, (menstrual cycles where ovulation fails to occur). Menstrual pain can directly be linked to the amount of alcohol consumed in the lead up to the menses and consumptions of alcohol, even small amounts, exacerbates most gynaecological conditions. These changes can drastically decrease a woman’s chance of becoming pregnant and thus affect fertility.

Alcohol effects fertility in both partners, and can do so in so many ways. For couples who desire to have a baby, it is best to stay away from drinking completely. Presently there is no safe limit of alcohol intake; even socially acceptable amounts of alcohol can affect fertility potential and outcomes. Moderate drinking (1-2 drinks in one sitting) is probably okay, especially if you reserve those drinks to a few times a week, instead of daily. However, if you’re going through IVF treatment, or trying to conceive naturally, you might consider cutting out alcohol for the time being. A woman that is trying to concieve, or trying to improve a gynaecological issues, or menstrual issues, should not be consuming more than 4 standard drinks per week. A male who is trying to conceive, or have sperm quality issues, should have no more than 2 standard drinks in one sitting and be having at least 2 alcohol free days per week. These are all part of the healthy drinking set out in health department and government safe drinking guidelines.

Trying to conceive is a special time in a couple’s life, it should be filled with love, devotion and safe health practices, which means a healthy diet and lifestyle and having a healthy mind too. It also means having healthy drinking habits as well.

Decreasing alcohol, having bete foods and looking at a healthy detoxification program is also a great idea for those trying to increase their fertility and get their reproductive systems working better. Healthy eggs and health sperm make healthy babies. Healthy reproductive systems also mean better menstrual cycles and better testicular health too.

Safe drinking everyone

Regards

Dr Andrew Orr

(Reproductive Medicine & Women’s Health Specialist)

– The International Baby Maker

-Women’s and Men’s Health Advocate

– No Stone Left Unturned

Sex Around The Time of Embryo Transfer Increases The Likelihood of Successful Early Embryo Implantation and Development.

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One of the things that I  promote is that regular sex is so important for our fertility patients, on so many levels. Sometimes the obvious eludes some people though

One of the things I see quite regularly is that couples doing Assisted Reproduction (ART) are abstaining from sex fearing it will affect their chances of conceiving. Actually the opposite is true. By not having sex during ART cycles (IUI, IVF etc) you are affecting your chances of conception.

I have often spoken about the importance of sex and orgasm assisting implantation in other posts and there is so much medical research to back this up

Let me ask the question “If you were trying naturally, would you stop having sex for fear that conception has taken place?”

Then why would you stop having sex around an ART cycle?

Let’s face the facts, implantation takes place in the uterus, and not the vagina, and no man is that well endowed to even penetrate the cervix, so…. Let’s get a grip here

The question to ask is “What does an embryo feed off and need to successfully implant?”

The answer is blood!

Think of a tick borrowing into skin to feed off its host.

How do you get blood flow into the uterine lining?

The answer is that sex and climax stimulate blood flow to the lining to assist implantation and also prepare the lining for implantation!

Nature has given us all the tools for healthy conception to take place, and yet many of us just aren’t using them.

This article shows that sperm are also beneficial in assisting implantation and exposure to semen around the time of embryo transfer increases the likelihood of successful early embryo implantation and development.

http://humrep.oxfordjournals.org/content/15/12/2653.full

Don’t forget that regular sex during this time not only helps assist implantation, but it also helps with the bonding process and physical connection process during this stressful time. Many couples split up because of losing this connection during the ART process and sex is a way of keeping that physical and emotional connection. Sex also tells your body you are also preparing to conceive on another level too.

For those doing IVF etc, next time you are doing an ART cycle maybe it is time to start doing things the way nature intended to give you that boost you so desperately are needing. Time to go and get busy people.

Regards

Dr Andrew Orr

Reproductive Medicine and Women’s Health Medicine Specialist

-The International Baby Maker

– No Stone Left Unturned

Seminal fluid improves fertility women and improves IVF pregnancy rates

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Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the female egg, but a more complex function in influencing female reproductive physiology is now evident
Remarkably, seminal fluid contains special signaling agents that interact with the female reproductive tract to prime the immune response, with consequences for fertility and pregnancy outcome. This research isn’t new and we have spoken about this in previous posts. But we now know a bit more about how sperm may assist in implantation for, especially for IVF.

See my other post https://drandreworr.com.au/sex-around-the-time-of-embryo-transfer-increases-the-likelihood-of-successful-early-embryo-implantation-and-development/

Recent studies demonstrate a key role for seminal fluid in enabling  embryo implantation and optimal placental development. In particular, seminal fluid promotes health immune responses which facilitate embryo implantation by suppressing inflammation, assisting uterine circulation and blood supply and also protecting the embryo.

There is emerging evidence  where seminal fluid provokes an adaptive immune response in the cervical tissues after contact at intercourse, and spermatozoa accessing the higher tract potentially affect the endometrium directly. Research has now shown that sperm and seminal fluid actually help with endometrial receptivity, which is needed to create the right environment for a healthy embryo to implant.

These biological responses may have clinical significance, explaining why

[1] intercourse in IVF ET cycles improves the likelihood of pregnancy

[2] inflammatory disorders of gestation are more common in women who conceive after limited exposure to seminal fluid of the prospective father

[3] preeclampsia incidence is elevated after use of donor oocytes or donor sperm where prior contact with conceptusalloantigens has not occurred.

Research like this is important to define the mechanisms through which seminal fluid interacts with female reproductive tissues, to provide knowledge that may assist in preconception planning and infertility treatment. It also bring attention to the fact that couples still need to be engaging in regular intercourse during IVF cycles to help not only with implantation, but to increase pregnancy rates through optimization on the endometrial lining through contact with seminal fluid. Regular intercourse also promotes connection and bonding for the couple as well and this is something that is very much overlooked.

My clinic offers a comprehensive Fertility Program where couples are educated on important factors such as this… and more

If you would like to find out how you could improve your chances of having a baby, please give my clinic a call and ask about my highly successful fertility program that has helped over 12,500 babies (and counting) into the world and can increase a couples chances of conception by 96.1% *

For more information on my highly success fertility program, see also https://drandreworr.com.au/fertility/fertility-program/

Regards

Dr Andrew Orr

Reproductive Medicine and Women’s Health Medicine Specialist

-The International Baby Maker

-No Stone Left Unturned

Why Sperm Is The 51st Shade of Grey

Recently I have put up some serious posts about sperm and sperm quality and the importance of not storing it up, because it actually makes the sperm quality worse. It was intended for people trying to actually have a baby, but many of those still practicing, and not making, loved the post as well.

It is still good to promote healthy sperm production and reproductive function, even if you aren’t trying to have a baby.

But, while my post did raise a few eye bows, and caused a few giggles, or “There you go dear, I told you we need to have sex more often”.

However, I did see that there were some major misperceptions around the topic of sperm. So, I thought I’d better educate you all on the finer details of sperm

Biology 101 tell us that it takes a sperm and an egg, not just an egg (as many people seem to forget), to make a baby. The trouble is,over 50% of fertility issues are related to poor quality sperm and 85% of miscarriage issue are related to a man’s swimmers. So what do guys do when they hear this?

Well, they bury their heads in the sand and say “My boys are fine, I just know they are” and guzzle some more alcohol, that has their swimmers having two heads, two tails and swimming around like a drunk man in a pool. Guys are shockers when it comes to keeping their sperm healthy and why I will always be in business for fertility services.

But besides the downside of men and sperm, there are some good points to sperm, but most of the time Dr Google has you all believing things that just aren’t true at all.

So lets look at the facts about Sperm.

  1. Sperm can help fight depression in women– Research has shown that have oral sex, or unprotected sex (not that I advocate this unless in a healthy relationship), have less depression, have healthier moods and have healthy immune systems and are happier in general. Sperm helps increase oxytocin, prostaglandins and seretonin in women according the The State University of New York study.
  2. Sperm can make you more fertile – Semen isn’t just vehicle for carrying sperm – it also plays a crucial role in triggering ovulation, according to a new study.Scientists have discovered the protein in the sexual fluid acts as a hormonal signal on the female brain.This triggers the release of other hormones that signal the ovaries to release an egg.
  3. Sperm can help Embryo Implantation– Studies have shown that sperm actually assist in embryo implantation via several chemicals and hormones. Yet many people are told refrain for having sex after IVF. I can tell you that you need to have more sex and not listen to the BS and listen to the research that proves otherwise.
  4. Storing up sperm does not make it better– Research has shown that regular ejaculation improves sperm quality and the resulting transport of seminal fluids. (as was told to you in previous posts). Storing it up, does not make it better, it makes it worse. Regular ejaculation also helps the prostate.
  5. Sperm do not last for days– On ejaculation into a woman, most of the 300-500 million sperm that set off are dead within an hour and only about 5-10 single sperm actually survive the journey to the tubes, where many more half of those die off once more. Sperm are killed by acids,killed by the woman’s immune system, die in the uterus, get lost in the uterus, die on the tubes and so on. Only the fittest survive the race to pregnancy. (The human body series BBC)
  6. You can cook with it– Yep, there are cooking books that use semen to cook recipes with. (Natural Harvest – A Collection of Semen-Based Recipes). Where semen is described as “Semen is not only nutritious, but it also has a wonderful texture and amazing cooking properties. Like fine wine and cheeses, the taste of semen is complex and dynamic” Well there you go, crack open the bottle of grange now.
  7. Sperm is good for your skin– Sperm contains minerals such and zinc, vitamin C, prostaglandins, collagen, vitamins, amino acids and many other health things to help with skin. Bioforskning, a Norwegian company, has synthesized the compounds into a facial cream. According to Bioforskning, the cream Spermine is 30 times more effective than vitamin E and can delay the aging process by 20 percent. However, nature’s most natural facial cream can cost you a whopping $250. I’d like to see them try to market that at Myer 🙂
  8. The first sperm under a microscope- Antonie van Leeuwenhoek was the person to view sperm under a microscope. It’s a bright day in 1677, in the city of Delft, and Antonie van Leeuwenhoek is making love to his wife. But moments after he shudders with orgasm, he hurries out of bed to grab his microscope. After all, he’s not just spending time with his wife: he’s running an important scientific experiment at the request of the Royal Society in London. Sounds like nothing much has changed for some men. Now some are just rushing to watch the footy.

Well, there you go. 8 things Wikipedia can’t tell you about sperm. The good, the bad and the down right outrageous. You heard it hear first. The doc provides you news that other people are to scared to report. I hope all of you have a great up and coming week. Pardon the pun. Life is too short to be serious, about a serious topic.

References

1.http://www.dailymail.co.uk/health/article-2190863/Semen-good-womens-health-helps-fight-depression.html

2.http://www.dailymail.co.uk/health/article-2191495/Does-having-sex-make-women-fertile-Semen-trigger-ovulation-mammals.html

3.http://humrep.oxfordjournals.org/content/15/12/2653.short?rss=1&ssource=mfr

4 & 5. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm – Cervical Mucus Interaction (4th Edition). Cambridge University Press, Cambridge, UK (1999)

6. Human Body Series (BBC) – Conception

7.http://cookingwithcum.com

8. http://www.medicaldaily.com/extraordinary-things-you-can-do-sperm-242190

9.http://rstl.royalsocietypublishing.org/content/9/101-111/121.full.pdf+html

Regards

Dr Andrew Orr

Reproductive Medicine & Women’s Health Specialist

The International Baby Maker and Women’s and Men’s Health Advocate

-No Stone Left Unturned

Adherence to a Healthy Diet a Must For Fertility Success

Is it time you that you got your diet healthier to get the baby you have been longing to have?

While eating a health diet isn’t going to be a miracle cure to having a baby, it can help you increase your fertility and chances of a healthy pregnancy. Of course, there are so many other factors to fertility and proper evaluation and assessment is crucial, but research does show that by adherence to a healthy diet can increase pregnancy rates by up to 80%.

It is well known that healthy couples produce healthy sperm and healthy eggs and healthy parents produce healthy babies. A proper healthy diet can also help with gynaecological conditions as well.

When I talk about diet, I am not talking about it in term of dieting. I am talking about it in terms of the proper way to way. Diet is such a crucial part of my highly successful fertility program that has helped over 12,500 babies into the world. So many people neglect a healthy diet and don’t try hard enough to adhere to it. Preparation for falling pregnant is just as crucial as preparing for a marathon. If you don’t put in the work, nutrients and the training, you won’t make the distance, or get a result.

It is so sad seeing people go through cycle after cycle and not doing anything to change their diet and lifestyle and then getting a failed cycle time and time again. Of course their can be other factors to take into consideration as I said before. But, you can’t go into a cycle, or try to fall naturally, if you not eating properly, or if you are overweight, or underweight for that matter. Medically we know that the risk of miscarriage, preterm delivery, complication etc is high in women who are either under, or overweight. (Lifestyle management before fertility treatment -Fertility & Sterility Journal 2007)

So many people think they have a good diet, only to find out that what they have been taught is not right. It isn’t their fault. Some people really just do not know what a healthy diet its either.

A poor diet that is high in High GI Carbohydrates causes inflammation and this has a negative impact on fertility. Inflammation is causes by high sugars, which then spikes your insulin and this causes the inflammatory response. This can also affect hormones as well. High inflammatory response then causes oxidation which then affects your egg and sperm quality and this can results in damage to the DNA of the sperm and egg.
As I shared before, a healthy diet is a part of my successful fertility program and those on it know what a good diet is supposed to be like. Yet we see many ignoring it and wondering what has gone wrong, or what else they can do.

The simple answer is, be good with your diet!
Close enough is not good enough in this case. It is all or nothing, because this is so important. This is about having a baby. But, while having a baby is one thing, we also need people to realise that a healthy diet is also important for living a long and healthy life long after baby has arrived.

If you are overweight, you need to lose weight and if you are underweight you need to put some on. Many people are looking for miracles and go looking for an answer that doesn’t exist, or blame something else, when the fix may be as simple as adhering to a healthy eating regime. Again, obviously diet is only a small piece of the puzzle when it comes to fertility, but it is an important one at that.

There is so much medical research out there showing that adhering to a low GI diet and the diet I promote at my clinic and for those of my fertility program

  1. The nurses study of 17,500 women showed that a diet with protein, full cream dairy, multivitamins and supplements, good fats etc increased fertility rates exponentially. (Journal of Obstetrics and Gynaecology, Nov 2007)
  2. Harvard medical schools study on 19,500 women showed that having full fat diary increased fertility while low fat dairy decreased it by 85 % and had an anovulatory effect. (Journal of Fertility and Sterility Feb 2008)
  3. A recent study in the Journal of Fertility and Sterility showed that diet increased embryo quality and pregnancy rates by as much as 80%. In a study presented at the American Society of Reproductive Medicine (ASRM) in 2012, IVF patients who switched to a low-carbohydrate, high-protein diet and then underwent another an IVF cycle increased their blastocyst formation rate from 19% to 45% and their clinical pregnancy rate from 17% to 83% (Fertil Steril. 2012;98[Suppl]:S47).

Even non-IVF patients with polycystic ovarian syndrome and endometriosis have improved pregnancy rates after making dietary and lifestyle changes.There are many other research papers out there showing this.

So if you are having failed cycle after failed cycle, or not being able to conceive naturally, you need to start looking at your diet and lifestyle as a major factor. If you are on my fertility program you should be doing this. If you aren’t, you need to, and if you need help again, you need to book back in with me for a consult and go back over it again. If you are overweight, or underweight, the same applies. An easy way to work out what weight should be (roughly), is take 100cms off your height and this will give you what you should be in body mass. So if you are 165cms tall, then you should roughly be about 65kgs (give or take a few kilos). All men should have a waist size of 94cm or below for good health, and all women should have a waist size of 80cms or below for good health. This is measured from the belly button around, not higher, or lower than this point.

I always tell my patients that the time for making excuses is over. If you do want to have this baby you have been longing to have, then you need to prepare the body as though you were about to train for a marathon. We always say that the ones that do everything right get the results and get that baby they have been longing for.

Is it time you got your diet and lifestyle back on track?

Take care

Regards

Dr Andrew Orr

Reproductive Medicine and Women’s Health Specialist

-The International Baby Maker

-No Stone Left Unturned