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Western Diet Permanently Alters the Immune System & Alters Gene Expression

For many years we have been trying to explain to people how their diet is a major factor in their current health and how a poor diet can actually cause expression of many inflammatory disease states within the body. There is now research which shows how the western diet permanently alters the immune system and alters gene expression.

New research has shown that our immune system responses to the Western diet very similar to how it reacts to infection by dangerous bacteria. The research was led by the University of Bonn in Germany and published in the journal Cell.

One of the disturbing results of the study is that the longer we consume a high GI, highly refined foods, and Western diet, that it can make the immune system become hyper-responsive to inflammation triggers. We know that a diet in highly processed foods and refined carbohydrates actually causes high inflammation in the body.

The longer we eat this way, these long-term changes may contribute to type 2 diabetes, arteriosclerosis, inflammatory bowel conditions, cancers,  gynaecological conditions,  and several other conditions wherein inflammation is thought to play a part, and which have been linked to consumption of a highly refined Western based diet.

The Western diet altered gene expression

The new research showed that just after just 1 month, there were changes throughout the bodies that are similar to the strong inflammation reactions that occur in bacterial infections. The researchers showed that an unhealthy high GI/highly refined diet led to increases in certain immune cells, which were a sign of inflammation and an infection like process. They also found that the Western diet had switched on many genes in the body that would also express many disease states and inflammatory processes in the body.

The researchers concluded that  findings highlight the dramatic impact that the wrong kind of food can have, and that they have important implications for society, especially for children who grow up with this highly inflammatory based diets and consume them longer.

The researchers concluded that adults and children have a choice of what they eat every day. We should enable everyone, especially children,  to make conscious decisions regarding their dietary habits. The new research also highlighted that dietary habits and the foundations of what a healthy diet is, need to become more prominent in our education system and it needs to start at a younger age. We also need to re-educate adults on what a healthy diet is as well

At my clinic, we can help people to know what a healthy diet is and this education is also passed onto people we help with inflammatory disease states.

We always promote a Primal/Low GI/grain free diet to all our patients so that they can be healthier, have less inflammation in their bodies and live longer and happier lives.

Regards

Dr Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Expert

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Endometriosis Awareness Month March 2019

Dr Andrew Orr has an honest and open talk about Endometriosis Awareness Month and also about the disease itself.

Dr Andrew Orr talks about the facts, the myths and what women with endometriosis go through on a daily basis.

He also discussed that there is help out there and what is needed in a multi-modality (team like) approach to care and ongoing management of the disease

Lastly, he wants every women, and man, to know that Period Pain IS NOT Normal and that women do not need to suffer in silence. There is always help out there and you just have to find the right people who will care, listen and help you in every aspect that you need.

Dr Andrew Orr has a special interest in Endometriosis and does research and lecturers about this horrible disease that affects 1 in 10 women world wide. If you do need help with period pain, or endometriosis and the associated symptoms, please give his clinic a call. Please do not suffer in silence alone. There is help out there. Dr Andrew Orr’s motto is “No Stone Left Unturned” and he uses this to assist all his patients.

Take care

Regards

Dr Andrew Orr

-No Stone Left Unturned

-Women’s and Men’s Health Expert

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Endometriosis IS NOT an Autoimmune disease

There are many statements made about endometriosis and many of them are not factual. This goes for the statement that Endometriosis is an autoimmune disease. In this article I will explain why this statement is false, and not true, and the reasoning behind it.

Everyday I get people telling me all sorts of facts and fictions they have heard on Dr Google. As I always say to people, Dr Google is not a reliable source of health information, unless it is from peer reviewed medical sites. Even then these sites are pretty much restricted to the general public.

Many people are looking for the miracle cure for endometriosis, or the holy grail of causes of it, and why wouldn’t you if this was affecting your life. I know from personal experience with health issues, I do want to know what the cause is and how to treat it.

But like so many conditions many people face each day, sometimes there is no answer just yet. Sometimes we don’t have all the answers and that is just how it is. When this is the case for a disease, I always tell my patients to not get caught up so much on the cause, but rather do the known treatments and management to get better. This is what really matters the most. Plus, like any disease, we need to look at treating the individual and not treat the masses.

Many diseases like endometriosis need a multi-modality approach to treat them effectively and this how I treat my patients and why I have so much success with treating endometriosis. It is about employing the right treatments and treatments that work.

Endometriosis does not fit the classification of an Autoimmune Disease. 

What we do know is that endometriosis is made worse through diet and lifestyle and external influences. We also know that internally there are many things that exacerbate endometriosis too. Behind it all, it is an inflammatory based disease. Any inflammation in the body makes it worse. Plus, endometriosis itself can inflame the body too.

Endometriosis is very much an ‘autoimmune like’ disease, because inflammation is a major driving factor, but it isn’t an autoimmune disease. Endometriosis does not fit the classification of an autoimmune disease as it does not produce auto-antibodies. We also know that endometriosis is normal tissue growing in abnormal areas. Again not producing auto-antibodies.

What we do know

We know that retrograde menstruation is a big factor for some women, but we also know that retrograde menstruation isn’t a factor for others. What we do know is that estrogen is a big driving factor and that endometriosis is estrogen driven. It isn’t from estrogen dominance, or estrogen excess either. What we do know about endometriosis, is that like autoimmune diseases, it is also passed on via genetic and hereditary factors. But again, endometriosis is not an autoimmune disease and does not fit the classifications of an auto-immune disease at this stage.

Like many diseases we get in our body, we often have other disease states expressed at the same time and can be purely coincidental. Some can come from hereditary factors and people are just predisposed to getting this diseases and when the body is inflamed, it just causes this other diseases to be expressed too. If someone has an autoimmune disease and also has endometriosis, this does not mean that endometriosis is autoimmune. There are many women who have endometriosis and who do not have autoimmune diseases as well.

Inflammation is a driving factor 

If a woman has an autoimmune disease at the same time as endometriosis, this is purely coincidental, or it is another hereditary factor that may have been passed onto them through their parent. It needs to be treated independently and not as part of endometriosis. It is all inflammation at the end of the day, so addressing inflammation and immune response will not only help the secondary autoimmune disease, but it will also help the endometriosis.

I’ve talked about the facts and fictions of endometriosis before and we really cannot say endometriosis is an autoimmune disease, because there is no credible, or conclusive research to back that up at this stage.There maybe in the future, but at this stage there is not, so we cannot say that endometriosis is an autoimmune disease.

Is the immune system and inflammation a part of endometriosis? … It sure is

Is endometriosis and autoimmune disease? … It isn’t at this stage

Hope this helps to shed some more light on this disease that affects so many women around this world. Hopefully one day soon we will have all the answers and we can end the horrible world of endometriosis.

If you want to find out more about how endometriosis is not an autoimmune disease, have a read of this great article by A/Prof Jason Abbott from Endometriosis Australia’s page. Click Here

Regards

Dr Andrew Orr

-Women’s Health Expert

-Endometriosis Expert

-No Stone Left Unturned

-“Period Pain is Not Normal”

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Von Willebrand Disease

Von Willebrand Disease (VWD) is the most common inherited bleeding disorder diagnosed in women with heavy abnormal uterine bleeding, due to a coagulation defect. Women with this disease may also have some tendency to bruising/nosebleeds in childhood but it will be when they get there first period that deficiency in von Willebrand factor – an essential protein required for both normal platelet function and as a co-factor to Factor VIII in the clotting cascade, most frequently presents.

A parent with VWD has a 50 per cent chance of passing the affected gene on to each child. VWD can affect both men and women. Sometimes genes mutate or change and can skip generations. Sometimes a child may have VWD but there was no family history of the condition. This means that VWD can occur in any family.

Women with this condition will present with excessive or prolonged bleeding with all other investigations normal (e.g. structural abnormalities are excluded). The diagnosis of Von Willebrand’s disease is by means of a coagulation screen and vWF antigen testing.

History behind Von Willebrand’s disease

Von Willebrand’s disease is named after Dr Erik Adolf von Willebrand, a Finnish paediatrician. In 1924, a 5-year-old girl was brought to the hospital in Helsinki where von Willebrand worked. He diagnosed her with a bleedingdisorder which he recognised was different from the haemophilia which was initially suspected. He subsequently assessed 66 members of her family and in 1926 first described the disease and its inheritance. Von Willebrand’s disease is the commonest coagulation defect in humans-but is also seen in dogs (notably Doberman Pinschers),and more rarely in swine, cattle, horses, and cats.

Symptoms of Von Willebrand’s Disease

Many people with the disease do not have any symptoms. Those who do may find that they:

  • have lots of nosebleeds
  • bruise easily
  • have heavy menstrual (period) flow
  • bleed excessively from the mouth.
  • The presence in your menstrual flow of blood clots greater than 1 inch (2.5 centimeters) in diameter
  • The need to change your menstrual pad or tampon more often than hourly
  • The need to use double sanitary protection to control menstrual flow
  • Symptoms of anemia, including tiredness, fatigue or shortness of breath

There are three main types of VWD:

  • Type 1
  • Type 2
  • Type 3.

These can be broken down into further categories. The most common are types 2A and 2B.

Complications of von Willebrand disease may include:

  • Anaemia– Women who experience heavy menstrual bleeding are more at risk of iron deficiency anaemia.
  • Swelling and pain-If abnormal bleeding occurs in the joints or soft tissue, swelling and severe pain can result.
  • Death from bleeding –Rarely, someone with Von Willebrand’s Disease may experience uncontrolled bleeding that can be life-threatening and needs emergency medical attention.

There are hormones and other medications that can help with the acute bleeding that can present with VWD.

Although Von Willebrand’s Disease is the most common pathology, other bleeding disorders including thrombocytopaenia and haemophilias should be considered. Consultation with a haematologist should be considered when a coagulation defect is diagnosed, or when the history suggests a clotting disorder. The main aim is to to manage the underlying disease but to also help with effective menstrual regulation (usually with combined contraceptive pills).

Regards

Dr Andrew Orr

Women’s and Men’s Health Advocate

-No Stone Left Unturned

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Genetics & Gene Sequencing May Be The Path To a Cure for Endometriosis

I have always said that the biggest inroads to the management and treatment of endometriosis will come from the area of genetics. I’ve also said that if there is going to be a cure, this will be the pathway that is comes from.

New research published in the New England Journal of Medicine has revealed that Gene sequencing has found a set of genetic mutations which may help to develop molecular tests to distinguish between mild and aggressive types of endometriosis. This is a big step forward into finding out more about endometriosis and developing better medical treatments and management strategies. Hopefully one day it will also lead to a cure for women with this horrible disease.

Endometriosis is a painful disorder in women which uterine tissue grows outside of the womb, most commonly into the abdomen, and will affect at least 1 in 10 women. It can spread to every part of the body.

Many women with endometriosis will experience symptoms of abdominal pain, migraines, pain with sex, ovulation pain, IBS like symptoms, UTI like symptoms (without infection present), menstrual cramps, abdominal distension and possible issues with infertility.

Endometriosis can affect both physical and mental health in sufferers. While a portion of women with endometriosis get pain and associated symptoms, it needs to be noted that a significant portion of women with endometriosis are asymptomatic (no symptoms) and would not even know that had it, until they are investigated for fertility purposes.

This discovery helps moves towards developing genetic based systems for classifying endometriosis to sort out which forms of the disorder needs more aggressive treatment. Presence of the unusual set of mutations suggest that while origins are rooted in normal endometrial cells mutations change their fate, the mutations identified have links to genetic mutations found in some forms of cancer. Abnormal endometriosis tissue growth will often spread throughout the abdominal cavity but rarely becomes cancerous with exception to a few cases when the ovaries are involved.

The close links to cancer have always baffled scientists, as endometriosis does behave like a cancer the way it spreads, and now they have found some of the same mutations found in cancers, in some of the endometriosis lesions. But again, endometriosis rarely turns cancerous, except if it does spread to the ovaries, but there have been some studies to suggest links that women with endometriosis may be at more risk of endometrial cancer.

In this latest research, the research scientists analysed the samples looking for mutations or abnormal changes in DNA and filtered out normal variations in genes which commonly occur. At least one or more mutations in endometriosis tissue that were not present in their normal tissue, in which the number and type of mutations varied per endometriosis lesion and each woman.The types of mutations found were among the most common mutated genes found, which are all known for DNA repair, controlling cell growth, and cell invasion.

The researchers are working on additional studies to investigate whether patient outcomes correlate with the mutations. Testing which can sort lesions into less or more aggressive has potential to help decide how to monitor progression as well as control and treat the endometriosis. It may also be possible to develop new treatments which use agents that block gene related pathways specific to an individual’s disease.

Women are normally prescribed anti-hormonal treatments, which block estrogen to shrink lesions. Endometriosis is estrogen driven and is not from estrogen dominance, as some people would have women believe. Even small amounts of estrogen can drive the disease and cause the expression of the lesions. When endometriosis occurs on the ovaries and forms a large cyst, or endometrioma, it is typically removed as it increases the risk of developing ovarian cancer in some women.

While this new development is not a cure for endometriosis, it is providing new insights into the disease, which will hopefully one day see a cure in the not so distant future. Lets help end the silence for women with this horrible disease by getting more awareness out there and let us hope that the cure will eventually come one day soon.

Regards
Dr Andrew Orr
-No Stone Left Unturned
-Period Pain IS NOT Normal
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