The Serious Health Complications Of Unmanaged PCOS

Posted on February 19, 2020February 19, 2020 by Andrew Orr

Just like endometriosis, there is a lot of the information about PCOS, but it is more about the symptoms, time to diagnosis and future fertility outcomes.

While it is necessary to educate people about these things, nobody is really talking about the serious health complications of unmanaged PCOS.

There have been some big changes to the diagnosis of PCOS, but still it can often take up to 3 years or more to get a proper diagnosis. While it may not take as long as endometriosis to be diagnosed, it still means that many women are being missed and dismissed in those year before they are finally diagnosed.

Like Endometriosis, some women with PCOS are never diagnosed and some women do not have any symptoms and can have very regular cycles etc. Women can have PCOS and endometriosis together, alongside other issues such as adenomyosis as well.

There are serious health consequences with unmanaged PCOS

The main thing I am trying to bring to everyone’s attention is that it doesn’t matter what disease you have, if it is left unmanaged, or not managed properly, it can have some pretty serious consequences of ones fertility, and mental and physical health.

PCOS is not exception. While the symptoms of PCOS are not as bad as those suffered with endometriosis, or adenomyosis, women can still suffer in many other ways. The long-term consequences of unmanaged PCOS can be very serious and can also lead to early death (cardiovascular disease, stroke etc.) and also lead to certain cancers.

Risk factors

PCOS is thought to have a genetic component. People who have a mother or sister with PCOS are more likely to develop PCOS than someone whose relatives do not have the condition. This family link is the main risk factor.

Then there is the insulin resistance factor with PCOS as well. Insulin resistance is a primary driver of PCOS and there is now evidence to show that most, if not all, women with PCOS have insulin resistance by default. Again this appears to be through genetic or family links of someone having PCOS, or having diabetes in the family tree etc.

Excess insulin is thought to affect a woman’s ability to ovulate because of its effect on androgen production. Research has shown that women with PCOS have low-grade inflammation that stimulates polycystic ovaries to produce androgens.

This is why diet and lifestyle interventions are so important in the overall management of PCOS. It is because these changes help with the insulin resistance.

There are other risk factors such as obesity, stress, nutritional deficiencies and sedentary lifestyle. Have a look at my page about more information on PCOS and risk factors etc (Click Here)

The Common Symptoms of PCOS

It is important to know what the common symptoms of PCOS are, so that women and healthcare professionals alike know what to look for.

The common symptoms of PCOS include:

irregular menses
excess androgen levels
acne, oily skin, and dandruff
excessive facial and body hair growth, known as Hirsutism
female pattern balding
skin tags
acanthosis nigricans, or dark patches of skin
sleep apnea
high stress levels
depression and anxiety
high blood pressure
infertility
Increased risk of miscarriage
decreased libido
high cholesterol and triglycerides
fatigue
insulin resistance
type 2 diabetes
pelvic pain
weight management difficulties including weight gain or difficulty losing weight

Early Intervention and management is crucial

The causes of PCOS are unclear, but early intervention, early diagnosis and early management, can help relieve symptoms and reduce the risk of complications. Anyone who may have symptoms of PCOS should see their healthcare provider, women’s healthcare specialist, or PCOS expert.

Coping with the symptoms of PCOS and managing the treatments can be demanding ands sometimes stressful. But, to then learn there can be serious complications and added risks to your health from PCOS not being managed properly can be distressing.

Be educated and get proper help

Just like any disease state just being aware, and being educated there are added risks is an important first step. Once you have the common symptoms of PCOS under control then you can turn your mind to thinking about ways to prevent further complications. The good news is that many of the treatments and management strategies you will use for your PCOS will also help to prevent many of the serious complications. A qualified healthcare professional, or a healthcare practitioner who is an expert in PCOS should be managing anyone with PCOS. Nobody should be trying to manage PCOS on their own without some form of professional help.

The serious complications of PCOS

Women with PCOS are thought to be at higher risk of having future heart disease or stroke. They are also at higher risk of diabetes, endometrial cancer and other cancers too.

What are the serious complications of unmanaged PCOS?

Besides the risk factors already mentioned, the serious complications of unmanaged PCOS are as follows:

Weight gain or obesity
Prediabetes
Type 2 diabetes
Cardiovascular disease
Metabolic syndrome (generally having at least two of high blood pressure, high cholesterol, obesity, high fasting blood glucose)
Endometrial cancer
Other cancers (breast, ovarian)
Sleep apnoea
Inflammation of the liver
Infertility
Increased Pregnancy induced hypertension and pre-eclampsia
Increased gestational diabetes
Increased risk of stroke
Increased risk of sudden death
Atherosclerosis
Psychological disorders
Mood disorders (anxiety, depression)

What you can do

If you are worried about the serious complications of unmanaged PCOS it is helpful to:

Get your symptoms of PCOS under control as a first step
Discuss any concerns with your healthcare practitioner, or women’s health/PCOS expert.
Learn about and understand your risks
Learn that early intervention and early healthcare management is the key to assisting any disease state.
Have your blood pressure, blood glucose and cholesterol checked regularly
Seek guidance and support to help with weight management and dietary and lifestyle management.
Remember that all body types can have PCOS, not just those who are overweight.
Do not try to manage the symptoms of PCOS on your own.

Final word

If you do need assistance with PCOS and would like my help, please call my friendly staff and found out how I may be able to assist you. There are options for online consultations and consultations in person.

As mentioned before the key to any disease is early intervention and early healthcare management and you taking the first steps to get the help you need. PCOS also needs a multimodality approach. There are many facets to it. Don’t put off your health. Just pick up the phone and make that appointment today. There can be some very serious consequences if you do, especially for some conditions such and PCOS.

Regards

Andrew Orr

-No Stone Left Unturned

-Master of Women’s Health Medicines

-The PCOS Experts

References

Ehrmann D et al. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan;91(1):48-53
Meyer C et al. Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. J Clin Endocrinol Metab. 2005 Oct;90(10):5711-6
McCartney CR, Marshall JC. Polycystic Ovary Syndrome. N Engl J Med 2016;375:54-64
Hull MG. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol. 1987;1:235–245. [PubMed] [Google Scholar]
Balen AH, Conway GS, Kaltsas G, et al. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10:2107–2111. [PubMed] [Google Scholar]
Tian L, Shen H, Lu Q, Norman RJ, Wang J. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. J Clin Endocrinol Metab. 2007;92(4):1430–1433. [PubMed] [Google Scholar]
Jungheim ES, Lanzendorf SE, Odem RR, Moley KH, Chang AS, Ratts VS. Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril. 2009;92(1):256–261. [PMC free article] [PubMed] [Google Scholar]
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25. [PubMed] [Google Scholar]
Palomba S, de Wilde MA, Falbo A, Koster MPH, La Sala GB, Fauser CJM. Pregnancy complications in women with polycystic ovary syndrome: new clinical and pathophysiological insights. Hum Reprod Update. 2015 Jun 27;:dmv029. [PubMed] [Google Scholar]
Anderson SA, Barry JA, Hardiman PJ. Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis. Int J Cardiol. 2014;176(2):486–487. [PubMed] [Google Scholar]
Hardiman P, Pillay OC, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003;361(9371):1810–1812. [PubMed] [Google Scholar]
Genazzani AR, Gadducci A, Gambacciani M. Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. Climacteric. 2001;4(3):181–193. [PubMed] [Google Scholar]
Barry JA, Azizia MM, Hardiman PJ. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(5):748–758. [PMC free article] [PubMed] [Google Scholar]
Broekmans FJ, Knauff EAH, Valkenburg O, Laven JS, Eijkemans MJ, Fauser BCJM. PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG. 2006;113(10):1210–1217. [PubMed] [Google Scholar]
Haoula Z, Salman M, Atiomo W. Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod. 2012;27(5):1327–1331. [PubMed] [Google Scholar]
Chittenden BG, Fullerton G, Maheshwari A, Bhattacharya S. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009;19(3):398–405. [PubMed] [Google Scholar]
Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr. 2007;86(3):s836–s842. [PubMed] [Google Scholar]

Poor Diet, Stress and Sedentary Lifestyle ups Risk of Developing PCOS

Posted on January 29, 2019September 8, 2019 by Andrew Orr

Polycystic Ovarian Syndrome (PCOS) is a hormonal/endocrine/reproductive issue and is on the rise due to unhealthy food habits, low physical activity and high stress levels, a new study has found.

It has long been known that insulin resistance and poor dietary and lifestyle habits increase the risk factors for developing PCOS. While being overweight is a risk factor for PCOS, women can be of any body type and still develop PCOS. Women of all body shape can still have poor dietary and lifestyle habits and this is every increasing in our modern world.

Increased refined foods, increased refined grains, increased refined sugars and a sedentary lifestyle are big factors in developing PCOS and also other health conditions such as Diabetes and Heart disease.

We also know that high stress levels can lead to high cortisol levels and high inflammation in the body and then also be drivers of PCOS and many of the conditions that go with this disease state.

What is PCOS?

Polycystic ovary syndrome (PCOS) is the most common hormonal/endocrine/reproductive disorder among women of reproductive age. Symptoms can include include

Irregular or absent menstrual cycle
facial hair growth and excess body hair (hirsutism)
Acne
Increase weight and increase body fat (all body types can have PCOS)
Infertility and difficulty conceiving

The condition has many physiological implications as well. It also results in emotional and psychological agony in affected women. For more information on PCOS, have a read of my page about “Polycystic Ovarian Syndrome”

A recently concluded study published on the 12^th January 2019, has revealed that uncontrolled or untreated PCOS can raise the risk of diabetes, heart disease and infertility. It has also been concluded that psychological issues such as anxiety and depression can also be the consequence of untreated PCOS. This study fits in with many other recent studies and has prompted changes to PCOS guidelines.

The study was conducted on two groups — one group of 150 patients with untreated/uncontrolled PCOS and the other group of 150 women who had controlled PCOS. The study found that those affected with PCOS followed a poor lifestyle, consumed excessive junk food, had no or low physical activity, more intake of refined carbohydrates and high stress levels.

The study also discovered that there was lack of awareness among the affected women and about 40 per cent were seeking information online. This is a major cause of concern as there is a lot of misinformation on the internet and this is leading to women trying to self-diagnose and go off recommendations of friends and internet groups, rather than healthcare professionals who specialise in this area.

During the study, one group was taking probiotics along with maintaining good lifestyle, while the other group was only maintaining good lifestyle. While both groups showed improvement, the group taking probiotics had additional improvement.

Good gut health and restoring the microbiome is something that I have always promoted in women, not only with PCOS, but other gynaecological/reproductive issues as well. New research has shown that healthy levels of good gut bacteria not only help with restoring the microbiome and gut and digestive health, but also help with reducing inflammation, helping with a healthy immune system and helping with psychological health and wellbeing as well.

Women with PCOS need to be properly diagnosed first and then treatments require a multimodality approach with diet and lifestyle interventions as well. Women with PCOS also need to be properly monitored and managed by a healthcare professional and not go off self-diagnosis and recommendation of untrained people.

The long term consequence of mismanaged, or unmanaged PCOS can be damaging on many levels many patients are not aware of this. The problem these days is that everyone wants a quick fix, or a magic pill, and when things don’t seem to be working, they get impatient and either change treatments, or opt advice from untrained people, or friends and this can be very dangerous.

While self-education is very important, self-management can also be detrimental as conditions such as PCOS requires constant motivation, guidance and proper healthcare management. This was also highlight as part of this recent study.

The study also highlighted that the top 3 issues with PCOS were irregular periods, hirsutism and weight issues. Irregular periods, or absent periods affect about 7 in 10 women with PCOS. Hirsutism or the extra hair on face or other parts of body are seen in 70 per cent cases, while 70 per cent to 80 per cent of women with PCOS are either overweight or obese.

But, women of all body types can have PCOS so this also needs to be noted. Many women put off being investigated for symptoms of PCOS because they believe they need to be overweight to have this condition. There also older healthcare practitioners who still believe this to be the case and this is why it often takes up to 3 years for a woman to be properly diagnosed with PCOS.

There are also other symptoms of PCOS that are often overlooked. Acne, dark patches on the skin on back of neck and others areas, skin tags, hair loss, anxiety, depression, difficulty in getting pregnant, recurrent miscarriages and sleep apnoea are other symptoms that a woman may have PCOS.

What the study concluded

Besides the known factors such and diet and lifestyle, the study highlighted that many women with PCOS suffered in ignorance and isolation. Many women with PCOS are often take up to 3 years to be diagnosed and many are misdiagnosed on the way.

The study also showed that many women with PCOS were unaware of the long term fertility and health consequences, and many hardly have any information given to the about this disease. Many women with PCOS are dependent on internet, friends, other people with the disease etc, as their main source of information.

The study also showed that while routine treatments for PCOS are needed, they can be expensive and less effective than proper dietary and lifestyle control. Poor diet and lifestyle and increased stress levels are a major reason for the rising prevalence of the disease.

In the study diet and lifestyle changes had a comprehensive impact in controlling other health problems like insulin resistance, diabetes, and hypertension. When women were overweight, or obese, and they reduced body fat, there was also improvement in the symptoms and their testing reports.

Probiotic supplementation also had an overall additional benefit in reducing the abdominal fat, LH:FSH ratio, total testosterone, LPS level, menstrual regularity and also preserving the gut and digestive function. The addition of probiotics to any treatment regime for PCOS needs to be looked at as it could be a new PCOS treatment modality in future.

There are many things women can do to help PCOS and the associated symptoms and the short term and long term health consequences of the disease. While diet and lifestyle interventions needs to be part of this and is the number one treatment for PCOS, women with PCOS do need to be carefully monitored by a qualified healthcare practitioner. This then ensures proper care, management and also accountability and also ensures the disease in properly monitored along with any other changes in symptoms. It also helps with monitoring future fertility and future health issues as well.

If you do need help, or assistance with PCOS, please give my friendly staff a call and find out how I may be able to assist you.

Regards

Andrew Orr

-No Stone Left Unturned

-The PCOS Experts

-The Women’s Health Experts

References

-https://doi.org/10.3389/fendo.2019.00346

The Facts About PCOS

Posted on July 30, 2018September 7, 2019 by Andrew Orr

These are some of the main Facts about PCOS

Regards

Andrew Orr

-No Stone Left Unturned

-Women and Men’s Health Advocate

-The PCOS Experts

Women’s Health Consultations with Dr Andrew Orr

Posted on March 19, 2018September 2, 2019 by Andrew Orr

Are you sick of Painful Periods?

Are you tired of the flares from Endometriosis?

Is your period irregular and messing with your life?

Are you getting bad acne?

Are you sick of having to put up with mood swings and hormone imbalance?

Sick of being “Missed” and “Dismissed” by healthcare professionals and friends telling you that your symptoms are normal?

Are you just not getting the answers to your health issues?

Do you just want to get your quality of life back and be able to do everything you want to do in life?

Getting Help

Many of the health and reproductive issues women face are not normal, but more importantly many of issues can be managed and assisted with right treatments and management protocols. The problem for most women, is knowing who to see, and where to start, for Women’s Health Consultations on the journey to a better life and better health.

Let Dr Andrew Orr Guide You Through Your Health Journey

Dr Andrew Orr’s multi-modality treatment approach (using medical science and complementary medicines) has helped and assisted thousands women with women’s health conditions locally, interstate and overseas.

Dr Orr has a special interest in conditions such as period pain, endometriosis, PCOS and menstrual irregularities and other women’s health conditions.. You can find out more on some of his social media articles.

If you need someone who cares, someone who listens and can be your caring guide every step of the way through the challenges you are facing, then you need to book in a consultation with Dr Andrew Orr.

Dr Andrew Orr’s mottos are the “Period Pain IS NOT Normal” and he has a “No Stone Left Unturned” approach to every person he guides, manages and assists through their journey to a better quality life and better health.

Dr Andrew Orr has seen women from all over Australia and all over the world and can see you for a consultation in person, or through online services. Through easy to use online services, Dr Orr can now see anyone from all over Australia, or anywhere in the world. *(conditions may apply)

If you are suffering from a particular women’s health condition, or unknown health issue, Dr Andrew Orr is here to care for you and guide you through his step by step multimodality health management protocols and get you the help and care that you are so desperately needing.

* To find more please call Dr Andrew Orr’s clinic, or submit an online enquiry through the website.

Acne Can Be a Major Sign That You Have Polycystic Ovarian Syndrome (PCOS)

Posted on February 13, 2018July 17, 2018 by epsoftwa

Polycystic ovary syndrome (PCOS) is the most common reproductive/endocrine disorder — and most common cause of infertility — affecting 9 -18% of women around the world. One of the major signs that you may have PCOS is acne on the face, or other parts of your body. Many women will have this one symptom overlooked and then have a major reproductive/endocrine disorder overlooked as well.

Despite the prevalence of this chronic condition, one-third of women diagnosed with PCOS saw at least three health professionals over the course of two years before receiving a diagnosis, according to a study from the University of Pennsylvania.

Polycystic Ovaries (PCO) is a characterised by multiple cystic growths on the ovaries. In large it is an endocrine and hormonal disorder, but it has potential to cause gynaecological and reproductive issues and these issues can be varied. Women with PCOS may not have cystic formation and just have symptoms that are part of the syndrome only (eg-acne, irregular cycle). PCO and PCOS really are two different conditions, but now they are both put under the one title of PCOS and this actually isn’t correct. Some women only have the cysts (PCO), while others have no cysts but have the syndrome (PCOS). Some have both. The one thing that they all have in common is that they all have insulin resistance. The other thing we know is that there is usually a family member with the same condition whom has passed the condition on genetically. Often the family member passing on the genetic traits, doesn’t even know that have the condition in the first place.

Recent studies have shown that there are “major gaps” in education and support for women with these conditions (PCO and PCOS). We see the same thing with other gynaecological conditions such as endometriosis and Adenomyosis and why these conditions can take up to a decade to be diagnosed properly

As a healthcare practitioner, I see these same issues with so many women waiting years to get a proper diagnosis and they have seen multiple healthcare professionals in both the medical and complementary medicine profession. It also creates confusion and anxiety for women who just want an answer to their condition and are not being diagnosed properly and also getting conflicting advice and treatment in the interim.

The signs and symptoms of PCOS are very clear and easily diagnosed, but many healthcare professionals end up focussing on one symptom, while overlooking the bigger picture and then these poor women get their condition missed.

Acne is one of the major signs of having PCOS and many women have his overlooked, or unaware that they may have a condition that could affect their fertility later on. If a women presents with Acne, irregular periods etc, I know there is a very good chance that she could have, or actually has PCOS. The problem for these women, as explained before is that healthcare providers and placing too much emphasis on only one of these symptoms, which is usually the Acne, or just that the cycle is irregular. Then women are then put on the Pill and these symptoms are masked for years, until they try and have a child and have difficulty doing so. The other issue is that the acne is often the focus, due to vanity reasons, and this is also why the many of the treatments for the acne are not working, because they are failing to treat the root cause of the issue. It just becomes one big vicious circle that goes round and round until someone finally diagnoses the actual cause properly.

Women with PCOS also have an increased risk of type 2 diabetes, gestational diabetes, metabolic syndrome and anxiety and depression, and studies have shown that the longer it takes for the condition to be diagnosed, the longer the patients condition begins to affect both their physical, emotional and reproductive health

The most common signs of PCOS are:

Absent, Irregular and Inconsistent menstrual periods,
Acne
Excess hair growth (some women can have hair loss too)
Central obesity

But many women with PCOS are of normal body weight and can actually be underweight too. It can affect women of any shape, weight or size. Some women with PCOS have regular menstrual cycles and can be fairly asymptomatic (meaning no symptoms) too

Just like endometriosis, women with PCOS are often missed and dismissed and the impact this has can be significant psychologically and also significant on their future fertility. There needs to be better health professional resources and international dissemination to improve diagnosis, education, management and reproductive and health outcomes.

I am always saying to healthcare professionals (medical and complementary medicine) that if you don’t know how to do your job properly, you don’t know how to diagnose conditions like PCOS or Endometriosis properly, or it is out of your scope of practice, get out of the way and refer these women onto people who are trained to diagnose and manage these conditions properly.

Lets, help put and end to PCOS and also put an end to Endometriosis and other inflammatory gynaecological conditions as well. Let’s break the silence and help women get the diagnosis and care they need. Early intervention and treatment is crucial for any disease state and let’s help women get this care sooner.

Take care

Regards

Dr Andrew Orr

-Women’s and Men’s Health Advocate

-“Period Pain IS NOT normal”

-“Leaving no Stone Left Unturned”

Acne Can Be a Major Sign That You Have Polycystic Ovarian Syndrome (PCOS)

Posted on January 30, 2018September 2, 2019 by Andrew Orr

Some women only have the cysts (PCO), while others have no cysts but have the syndrome (PCOS). Some have both. The one thing that they all have in common is that they all have insulin resistance. The other thing we know is that there is usually a family member with the same condition whom has passed the condition on genetically. Often the family member passing on the genetic traits, doesn’t even know that have the condition in the first place.

As a Reproductive Medicine and Women’s Health practitioner I see these same issues with so many women waiting years to get a proper diagnosis and they have seen multiple healthcare professionals in both the medical and complementary medicine profession. It also creates confusion and anxiety for women who just want an answer to their condition and are not being diagnosed properly and also getting conflicting advice and treatment in the interim.

Acne is one of the major signs of having PCOS and many women have his overlooked, or unaware that they may have a condition that could affect their fertility later on.

If a woman presents with Acne, irregular periods etc, I know there is a very good chance that she could have, or actually has PCOS.

The problem for these women, as explained before is that healthcare providers and placing too much emphasis on only one of these symptoms, which is usually the Acne, or just that the cycle is irregular. Then women are then put on the Pill and these symptoms are masked for years, until they try and have a child and have difficulty doing so.

The other issue is that the acne is often the focus, due to vanity reasons, and this is also why the many of the treatments for the acne are not working, because they are failing to treat the root cause of the issue. It just becomes one big vicious circle that goes round and round until someone finally diagnoses the actual cause properly.

The most common signs of PCOS are:

Absent, Irregular and Inconsistent menstrual periods,
Acne
Excess hair growth (some women can have hair loss too)
Central obesity

Take care

Regards

Andrew Orr

-Women’s and Men’s Health Advocate

-No Stone Left Unturned

-The Women’s Health Experts

There are serious health consequences with unmanaged PCOS

Risk factors

The Common Symptoms of PCOS

Early Intervention and management is crucial

Be educated and get proper help

The serious complications of PCOS

What are the serious complications of unmanaged PCOS?

What you can do

Final word

References

Ehrmann D et al. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan;91(1):48-53

Meyer C et al. Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. J Clin Endocrinol Metab. 2005 Oct;90(10):5711-6

McCartney CR, Marshall JC. Polycystic Ovary Syndrome. N Engl J Med 2016;375:54-64

Hull MG. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol. 1987;1:235–245. [PubMed] [Google Scholar]

Balen AH, Conway GS, Kaltsas G, et al. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10:2107–2111. [PubMed] [Google Scholar]

Tian L, Shen H, Lu Q, Norman RJ, Wang J. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. J Clin Endocrinol Metab. 2007;92(4):1430–1433. [PubMed] [Google Scholar]

Jungheim ES, Lanzendorf SE, Odem RR, Moley KH, Chang AS, Ratts VS. Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril. 2009;92(1):256–261. [PMC free article] [PubMed] [Google Scholar]

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25. [PubMed] [Google Scholar]

Palomba S, de Wilde MA, Falbo A, Koster MPH, La Sala GB, Fauser CJM. Pregnancy complications in women with polycystic ovary syndrome: new clinical and pathophysiological insights. Hum Reprod Update. 2015 Jun 27;:dmv029. [PubMed] [Google Scholar]

Anderson SA, Barry JA, Hardiman PJ. Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis. Int J Cardiol. 2014;176(2):486–487. [PubMed] [Google Scholar]

Hardiman P, Pillay OC, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003;361(9371):1810–1812. [PubMed] [Google Scholar]

Genazzani AR, Gadducci A, Gambacciani M. Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. Climacteric. 2001;4(3):181–193. [PubMed] [Google Scholar]

Barry JA, Azizia MM, Hardiman PJ. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(5):748–758. [PMC free article] [PubMed] [Google Scholar]

Broekmans FJ, Knauff EAH, Valkenburg O, Laven JS, Eijkemans MJ, Fauser BCJM. PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG. 2006;113(10):1210–1217. [PubMed] [Google Scholar]

Haoula Z, Salman M, Atiomo W. Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod. 2012;27(5):1327–1331. [PubMed] [Google Scholar]

Chittenden BG, Fullerton G, Maheshwari A, Bhattacharya S. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009;19(3):398–405. [PubMed] [Google Scholar]

Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr. 2007;86(3):s836–s842. [PubMed] [Google Scholar]

What is PCOS?

What the study concluded

Getting Help

Let Dr Andrew Orr Guide You Through Your Health Journey